DMBT1 Antikörper (N-Term)

Produktnummer ABIN2775367

Der Kaninchen Polyklonal anti-DMBT1 Antikörper wird verwendet zum Nachweis von DMBT1 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für DMBT1 Antikörper (N-Term) (ABIN2775367)

Target: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DMBT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-DMBT1 Antikörper

Bindungsspezifität: N-Term

Verwendungszweck: DMBT1 Antibody - N-terminal region

Sequenz: SWSTPSPDTL PTITLPASTV GSESSLALRL VNGGDRCQGR VEVLYRGSWG

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against DMBT1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DMBT1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP42352-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu DMBT1

Target: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Andere Bezeichnung: DMBT1

Hintergrund:

Background Information: Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system.

Gene Name: Deleted in malignant brain tumors 1

Alternative Symbols: SAG, GP340, SALSA, muclin

Protein Name: Deleted in malignant brain tumors 1 protein

Molekulargewicht: 258kDa

Gen-ID: 1755

NCBI Accession: NP_015568

UniProt: Q9UGM3

Pathways: Activation of Innate immune Response