DMBT1 Antikörper (N-Term)

Produktnummer ABIN2775367

Produktdetails anti-DMBT1 Antikörper

Target: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DMBT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: SWSTPSPDTL PTITLPASTV GSESSLALRL VNGGDRCQGR VEVLYRGSWG

Homologie: Human: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against DMBT1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human DMBT1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 2413 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu DMBT1

Target: DMBT1 (Deleted in Malignant Brain Tumors 1 (DMBT1))

Andere Bezeichnung: DMBT1 (DMBT1 Produkte)

Synonyme: GP340 antikoerper, muclin antikoerper, CRP antikoerper, CRP-[a] antikoerper, CRP-[b] antikoerper, Crpd antikoerper, DBMT1 antikoerper, gp300 antikoerper, p80 antikoerper, DMBT1 antikoerper, gp340 antikoerper, deleted in malignant brain tumors 1 antikoerper, deleted in malignant brain tumors 1 protein antikoerper, gp340 antikoerper, deleted in malignant brain tumors 1 S homeolog antikoerper, DMBT1 antikoerper, Dmbt1 antikoerper, LOC100064515 antikoerper, dmbt1 antikoerper, ST201phi2-1p340 antikoerper, dmbt1.S antikoerper

Hintergrund: Loss of sequences from human chromosome 10q has been associated with the progression of human cancers. The gene DMBT1 was originally isolated based on its deletion in a medulloblastoma cell line. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. The DMBT1 protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Transcript variant 2 (8.0 kb) has been shown to bind surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may not be a classical tumor supressor gene, but rather play a role in the interaction of tumor cells and the immune system.
Alias Symbols: GP340, MGC164738, muclin
Protein Interaction Partner: CDK6, COPS6, SUMO2, UBC, PARD6B, SFTPD, SFTPA1,
Protein Size: 2413

Molekulargewicht: 258 kDa

Gen-ID: 1755

NCBI Accession: NM_007329, NP_015568

UniProt: Q9UGM3

Pathways: Activation of Innate immune Response