BTRC Antikörper (beta-Transducin Repeat Containing) (C-Term)

Details for Product anti-BTRC Antibody No. ABIN2775273, Anbieter: Anmelden zum Anzeigen
Antigen
  • BTRC
  • Beta-TrCP
  • betaTrCP
  • btrcp
  • btrcp1
  • fbw1a
  • fbxw1
  • fbxw1a
  • fwd1
  • btrc
  • beta-TrCP
  • BETA-TRCP
  • FBW1A
  • FBXW1
  • FBXW1A
  • FWD1
  • bTrCP
  • bTrCP1
  • beta-TrCP1
  • btrc-a
  • Beta-Trcp1
  • Fbw1a
  • HOS
  • Slimb
  • b-TrCP
  • mKIAA4123
  • beta-transducin repeat containing E3 ubiquitin protein ligase
  • beta-transducin repeat containing
  • beta-TrCP
  • beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog
  • beta-transducin repeat containing protein
  • BTRC
  • btrc
  • LOC100634006
  • Btrc
  • btrc.S
Epitop
C-Term
14
11
10
8
4
2
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus)
58
11
10
2
2
2
2
1
1
1
Wirt
Kaninchen
37
21
Klonalität
Polyklonal
Konjugat
Dieser BTRC Antikörper ist unkonjugiert
3
3
3
2
2
2
Applikation
Western Blotting (WB)
54
29
27
24
8
6
5
3
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN973943.
Sequenz LVEHSGRVFR LQFDEFQIVS SSHDDTILIW DFLNDPAAHA EPPRSPSRTY
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 86%
Produktmerkmale This is a rabbit polyclonal antibody against Btrc. It was validated on Western Blot.
Reinigung Affinity Purified
Plasmids, Primers & others Plasmide, Primers & weitere BTRC products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Btrc (BTRC Antibody Abstract)
Hintergrund Btrc is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1.
Alias Symbols: Beta-Trcp1, FWD1, Fbw1a, KIAA4123, Slimb, b-TrCP, beta-TrCP, mKIAA4123, HOS
Protein Interaction Partner: ZRANB1, Tpx2, Taz, Per2, Cul1, Skp1a, Reg1, Stat1, Nfe2l2, Per1, Htt, Cops2, Ikbkb, Nkx3-2, Cdc25b, Nfkbia, Gli2,
Protein Size: 605
Molekulargewicht 69 kDa
Gen-ID 12234
NCBI Accession NM_001037758, NP_001032847
UniProt Q3ULA2
Pathways Zellzyklus, Hedgehog Signalweg
Applikations-hinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 605 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-beta-Transducin Repeat Containing (BTRC) (C-Term) antibody (ABIN2775273) WB Suggested Anti-Btrc Antibody Titration: 1.0 ug/ml Positive Control: Mouse Panc...
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