BTRC Antikörper (C-Term)

Produktnummer ABIN2775273

Produktdetails anti-BTRC Antikörper

Target: BTRC (beta-Transducin Repeat Containing (BTRC))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Kaninchen, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser BTRC Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LVEHSGRVFR LQFDEFQIVS SSHDDTILIW DFLNDPAAHA EPPRSPSRTY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against Btrc. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 605 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu BTRC

Target: BTRC (beta-Transducin Repeat Containing (BTRC))

Andere Bezeichnung: Btrc (BTRC Produkte)

Synonyme: BTRC antikoerper, Beta-TrCP antikoerper, betaTrCP antikoerper, btrcp antikoerper, btrcp1 antikoerper, fbw1a antikoerper, fbxw1 antikoerper, fbxw1a antikoerper, fwd1 antikoerper, btrc antikoerper, beta-TrCP antikoerper, BETA-TRCP antikoerper, FBW1A antikoerper, FBXW1 antikoerper, FBXW1A antikoerper, FWD1 antikoerper, bTrCP antikoerper, bTrCP1 antikoerper, beta-TrCP1 antikoerper, btrc-a antikoerper, Beta-Trcp1 antikoerper, Fbw1a antikoerper, HOS antikoerper, Slimb antikoerper, b-TrCP antikoerper, mKIAA4123 antikoerper, beta-transducin repeat containing E3 ubiquitin protein ligase antikoerper, beta-transducin repeat containing antikoerper, beta-TrCP antikoerper, beta-transducin repeat containing E3 ubiquitin protein ligase S homeolog antikoerper, beta-transducin repeat containing protein antikoerper, BTRC antikoerper, btrc antikoerper, LOC100634006 antikoerper, Btrc antikoerper, btrc.S antikoerper

Hintergrund: Btrc is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE, the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1.
Alias Symbols: Beta-Trcp1, FWD1, Fbw1a, KIAA4123, Slimb, b-TrCP, beta-TrCP, mKIAA4123, HOS
Protein Interaction Partner: ZRANB1, Tpx2, Taz, Per2, Cul1, Skp1a, Reg1, Stat1, Nfe2l2, Per1, Htt, Cops2, Ikbkb, Nkx3-2, Cdc25b, Nfkbia, Gli2,
Protein Size: 605

Molekulargewicht: 69 kDa

Gen-ID: 12234

NCBI Accession: NM_001037758, NP_001032847

UniProt: Q3ULA2

Pathways: Zellzyklus, Hedgehog Signalweg