Klotho Antikörper (N-Term)

Produktnummer ABIN2774900

Dieses Anti-Klotho-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Klotho in WB. Geeignet für Maus, Human, Ratte, Kaninchen, Pferd, Rind (Kuh) und Schwein.

Kurzübersicht für Klotho Antikörper (N-Term) (ABIN2774900)

Target: Klotho (KL)

Reaktivität: Maus, Human, Ratte, Kaninchen, Pferd, Rind (Kuh), Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Klotho Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Klotho Antikörper

Bindungsspezifität: N-Term

Sequenz: GAAPSDSPIV VAPSGAPSPP LSSTGDVASD SYNNVYRDTE GLRELGVTHY

Homologie: Cow: 93%, Horse: 93%, Human: 100%, Mouse: 92%, Pig: 91%, Rabbit: 92%, Rat: 92%

Produktmerkmale: This is a rabbit polyclonal antibody against Kl. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1014 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu Klotho

Target: Klotho (KL)

Andere Bezeichnung: Kl

Hintergrund: Kl may have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 241 and 874, suggesting it may be inactive as a glycosidase in vivo. It may be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1.
Alias Symbols: alpha-kl
Protein Interaction Partner: Trpv5, Fgfr4, Fgfr3, Fgfr2, Fgfr1,
Protein Size: 1014

Molekulargewicht: 116 kDa

Gen-ID: 16591

NCBI Accession: NM_013823, NP_038851

UniProt: O35082

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hormone Activity, Growth Factor Binding