Klotho Antikörper (Middle Region)

Produktnummer ABIN2776875

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch Klotho in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human, Maus, Ratte, Kaninchen, Pferd, Rind (Kuh), Hund und Meerschweinchen.Es wurde in 1 Publikation zitiert.

Kurzübersicht für Klotho Antikörper (Middle Region) (ABIN2776875)

Target: Klotho (KL)

Reaktivität: Human, Maus, Ratte, Kaninchen, Pferd, Rind (Kuh), Hund, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Klotho Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Klotho Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: KL Antibody - middle region

Sequenz: HAQNGKISIA LQADWIEPAC PFSQKDKEVA ERVLEFDIGW LAEPIFGSGD

Homologie: Cow: 79%, Dog: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against KL. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human KL

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP41554-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-Klotho Antikörper (ABIN2776875)

Ritter, Zhang, Delmez, Finch, Slatopolsky: "Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid, and aorta of uremic rats." in: Kidney international, Vol. 87, Issue 6, pp. 1141-52, (2016) (PubMed).

Details zu Klotho

Target: Klotho (KL)

Andere Bezeichnung: KL

Hintergrund:

Background Information: KL is a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss.This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Klotho

Alternative Symbols: HFTC3

Protein Name: Klotho

Molekulargewicht: 116kDa

Gen-ID: 9365

NCBI Accession: NP_004786

UniProt: Q9UEF7

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hormone Activity, Growth Factor Binding