ATF3 Antikörper (Middle Region)

Produktnummer ABIN2774825

Produktdetails anti-ATF3 Antikörper

Target: ATF3 (Activating Transcription Factor 3 (ATF3))

Bindungsspezifität: Middle Region

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Zebrafisch (Danio rerio), Saccharomyces cerevisiae

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ATF3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: PLGVSITKAE VAPEEDERKK RRRERNKIAA AKCRNKKKEK TECLQKESEK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 93%, Rat: 93%, Yeast: 75%, Zebrafish: 80%

Produktmerkmale: This is a rabbit polyclonal antibody against ATF3. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human ATF3

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 181 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu ATF3

Target: ATF3 (Activating Transcription Factor 3 (ATF3))

Andere Bezeichnung: ATF3 (ATF3 Produkte)

Synonyme: zgc:55526 antikoerper, ATF3 antikoerper, LRG-21 antikoerper, LRF-1 antikoerper, LRFI antikoerper, atf-3 antikoerper, activating transcription factor 3 antikoerper, activating transcription factor 3 L homeolog antikoerper, atf3 antikoerper, ATF3 antikoerper, Atf3 antikoerper, atf3.L antikoerper

Hintergrund: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. ATF3 represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters.Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.
Alias Symbols: -
Protein Interaction Partner: SUV39H1, BATF3, MAFF, CREB3, FOSL1, MAFG, JUNB, JUN, FOS, DDIT3, DBP, ATF2, CEBPG, CEBPE, CEBPA, ATF4, ATF3, BATF, HSP90AA1, SRA1, ZNF212, ID3, FHL2, SUMO1, SUMO3, HDAC10, HDAC5, HDAC6, HDAC4, HDAC3, HDAC1, SMARCA4, PDX1, ACTB, UBC, SUMO2, STAT1, MDM2, SM
Protein Size: 181

Molekulargewicht: 20 kDa

Gen-ID: 467

NCBI Accession: NM_001674, NP_001665

UniProt: P18847

Pathways: Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response