INPP5D Antikörper (C-Term)
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- Target Alle INPP5D Antikörper anzeigen
- INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
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Bindungsspezifität
- C-Term
- Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Hund, Meerschweinchen, Pferd, Kaninchen, Schwein
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser INPP5D Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- PPTPTPRPPL PVKSPAVLHL QHSKGRDYRD NTELPHHGKH RPEEGPPGPL
- Homologie
- Cow: 86%, Dog: 86%, Guinea Pig: 79%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 93%, Rat: 100%
- Produktmerkmale
- This is a rabbit polyclonal antibody against INPP5D. It was validated on Western Blot.
- Aufreinigung
- Affinity Purified
- Top Product
- Discover our top product INPP5D Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 1189 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
- Andere Bezeichnung
- INPP5D (INPP5D Produkte)
- Synonyme
- INPP5D antikoerper, 256.t00004 antikoerper, 13.t00027 antikoerper, ship antikoerper, ship1 antikoerper, AI323613 antikoerper, SHIP antikoerper, SHIP-1 antikoerper, SHIP1 antikoerper, s-SHIP antikoerper, SIP-145 antikoerper, hp51CN antikoerper, inositol polyphosphate-5-phosphatase D antikoerper, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 antikoerper, inositol polyphosphate 5-phosphatase antikoerper, inositol polyphosphate-5-phosphatase D L homeolog antikoerper, INPP5D antikoerper, LOC100446045 antikoerper, inpp5d antikoerper, EHI_159880 antikoerper, EHI_153490 antikoerper, inpp5d.L antikoerper, LOC100380693 antikoerper, Inpp5d antikoerper
- Hintergrund
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This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall, the protein functions as a negative regulator of myeliod cell proliferation and survival. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Alias Symbols: MGC104855, MGC142140, MGC142142, SHIP, SHIP1, SIP-145, hp51CN
Protein Interaction Partner: NOTCH2NL, KRTAP10-3, KRTAP10-9, KRTAP10-7, KRT40, KHDRBS3, KRT31, DAB1, SH3KBP1, XIAP, INPPL1, LRRK1, SHC1, PTPN11, UBASH3B, CD2AP, SYK, NCK1, GRB2, CBL, UBC, ARAP1, BCR, CLYBL, MME, EPOR, TRIP10, CD300LF, DOK3, LILRB4, INPP5D, FCGR2B, GAB2, DOK2, GAB1, D
Protein Size: 1189 - Molekulargewicht
- 131 kDa
- Gen-ID
- 3635
- NCBI Accession
- NM_001017915, NP_001017915
- UniProt
- Q92835
- Pathways
- T-Zell Rezeptor Signalweg, BCR Signaling, Warburg Effekt
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