PINK1 Antikörper (N-Term)

Produktnummer ABIN2764090

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PINK1 in WB, IHC und EIA. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PINK1 Antikörper (N-Term) (ABIN2764090)

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PINK1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Enzyme Immunoassay (EIA)

Produktdetails anti-PINK1 Antikörper

Bindungsspezifität: N-Term

Kreuzreaktivität: Human

Produktmerkmale: PTEN-induced putative kinase protein 1,Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation. Defects in PINK1 are the cause of Parkinson disease type 6 (PARK6). A neurodegenerative disorder characterized by parkinsonian signs such as rigidity, resting tremor and bradykinesia. A subset of patients manifest additional symptoms including hyperreflexia, autonomic instability, dementia and psychiatric disturbances. Symptoms show diurnal fluctuation and can improve after sleep.

Aufreinigung: Antigen Immunoaffiinity Purification

Immunogen: Synthetic peptide derived from the N-terminal of the human PINK1 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Antibody can be used for immunohistochemical staining (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu PINK1

Target: PINK1 (PTEN Induced Putative Kinase 1 (PINK1))

Andere Bezeichnung: PINK1

UniProt: Q9BXM7

Pathways: Autophagie