Influenza Nucleoprotein Antikörper (Influenza B Virus) (AA 1-560)

Produktnummer ABIN2754744

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch in ELISA und WB. Er zeigt eine Reaktivität gegenüber Influenza B Virus.

Kurzübersicht für Influenza Nucleoprotein Antikörper (Influenza B Virus) (AA 1-560) (ABIN2754744)

Target: Influenza Nucleoprotein (NP)

Reaktivität: Influenza B Virus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails

Bindungsspezifität: AA 1-560

Aufreinigung: Caprylic Acid Ammonium Sulfate Precipitation purified

Immunogen: Recombinant Influenza B virus Nucleoprotein protein(1-560aa)

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C/-80 °C

Antigendetails

Target: Influenza Nucleoprotein (NP)

Andere Bezeichnung: Influenza Nucleoprotein

Substanzklasse: Influenza Protein

Hintergrund: Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.

UniProt: P04665