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Influenza Nucleoprotein Antikörper (Influenza A Virus H2N2) (H1N1), (H2N2), (H3N2), (H5N1), (H5N2)

NP Reaktivität: Influenza A Virus H2N2 ELISA, WB, IF, IHC, IP, IC Wirt: Maus Monoclonal C43 unconjugated
Produktnummer ABIN2452039
  • Target Alle Influenza Nucleoprotein (NP) Antikörper anzeigen
    Influenza Nucleoprotein (NP)
    Bindungsspezifität
    • 15
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    H1N1, H2N2, H3N2, H5N1, H5N2
    Reaktivität
    • 64
    • 40
    • 15
    • 13
    • 11
    • 2
    • 1
    • 1
    • 1
    Influenza A Virus H2N2
    Wirt
    • 84
    • 44
    • 4
    Maus
    Klonalität
    • 86
    • 45
    Monoklonal
    Konjugat
    • 93
    • 10
    • 10
    • 6
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Unkonjugiert
    Applikation
    • 86
    • 57
    • 25
    • 15
    • 13
    • 13
    • 10
    • 9
    • 8
    • 7
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunochromatography (IC)
    Spezifität
    Reacts with NP of all influenza A viruses, including seasonal H2N2, H3N2, and avian H5N1, H5N2 and H1N1 (seasonal, pandemic and swine).
    Kreuzreaktivität (Details)
    No cross reactivity with influenza B viruses.
    Aufreinigung
    Purified by proprietary chromatography procedure under mild conditions.
    Reinheit
    90-95 % pure by SDS-PAGE
    Sterilität
    Sterile filtered
    Immunogen
    Human Influenza A Virus (H2N2) Okada strain
    Klon
    C43
    Isotyp
    IgG2a
  • Applikationshinweise
    1) Western blotting: 300~1,000 fold dilution
    2) Immuno-precipitation (100 fold dilution
    3) Immunofluorescent staining (200 fold dilution
    4) Immunohistochemistry (200 fold dilution
    4) ELISA (assay dependent)
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS, 50 % glycerol
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C
  • Mizuike, Sasaki, Baba, Iwamoto, Shibai, Kosaka, Kubota-Koketsu, Yang, Du, Sakudo, Tsujikawa, Yunoki, Ikuta: "Development of two types of rapid diagnostic test kits to detect the hemagglutinin or nucleoprotein of the swine-origin pandemic influenza A virus H1N1." in: Clinical and vaccine immunology : CVI, Vol. 18, Issue 3, pp. 494-9, (2011) (PubMed).

    Ueda, Yamate, Du, Daidoji, Okuno, Ikuta, Nakaya: "Maturation efficiency of viral glycoproteins in the ER impacts the production of influenza A virus." in: Virus research, Vol. 136, Issue 1-2, pp. 91-7, (2008) (PubMed).

    Okuno, Isegawa, Sasao, Ueda: "A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains." in: Journal of virology, Vol. 67, Issue 5, pp. 2552-8, (1993) (PubMed).

  • Target
    Influenza Nucleoprotein (NP)
    Andere Bezeichnung
    Influenza A (Nucleoprotein) (NP Produkte)
    Synonyme
    nucleoprotein antikoerper, NP antikoerper
    Substanzklasse
    Influenza Protein
    Hintergrund
    Influenza virus is an RNA virus, which causes influenza, and belongs to the family Orthomyxoviridae. Influenza virus is classified into three different genera, influenzavirus A, B, and C. They all have similar structures and compositions. The virions are 80-100nm in diameter and usually roughly spherical. The outer surface of the virion is made of a viral envelope containing two major glycoproteins, hemagglutinin (HA) and neuraminidase (NA). Influenzavirus A is further classified into subtypes based on the surface glycoproteins, HA and NA. Currently, there are 16 HA and 9 NA subtypes. The central core of the virion contains the viral RNA genome, which is packaged in the form of ribonucleoprotein complexes. Influenza virus nucleoprotein (NP) is a major component of the ribonucleoprotein complex and is abundantly expressed during the course of infection. It is a structural protein, which encapsidates the negative strand viral RNA and is essential for RNA transcription, replication and packaging. NP binds the PB1 and PB2 subunits of the viral RNA polymerase and the matrix protein M1, in addition to its binding to ssRNA. NP is also known to interact with variety of other macromolecules of both viral and cellular origins, and these interactions have been shown to be essential for the viral lifecycle.
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