PDE4A Antikörper

Produktnummer ABIN2750880

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PDE4A in WB, IHC, IF, ELISA, IP, ICC und CM. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte und Elch und wurde in 37+ Publikationen erwähnt.

Kurzübersicht für PDE4A Antikörper (ABIN2750880)

Target: PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))

Reaktivität: Human, Maus, Ratte, Elch

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE4A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA, Immunoprecipitation (IP), Immunocytochemistry (ICC), Confocal Microscopy (CM)

Produktdetails anti-PDE4A Antikörper

Aufreinigung: Affinity Purified

Immunogen: Synthetic cyclic peptide common to all PDE4A proteins.

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.65-1.00 μg/μL

Referenzen für anti-PDE4A Antikörper (ABIN2750880)

Avila, Barker, Zhang, McClain, Barve, Gobejishvili: "Dysregulation of hepatic cAMP levels via altered Pde4b expression plays a critical role in alcohol-induced steatosis." in: The Journal of pathology, Vol. 240, Issue 1, pp. 96-107, (2017) (PubMed).

Massimi, Cardarelli, Galli, Giardi, Ragusa, Panera, Cinque, Cifone, Biagioni, Giorgi: "Increase of Intracellular Cyclic AMP by PDE4 Inhibitors Affects HepG2 Cell Cycle Progression and Survival." in: Journal of cellular biochemistry, Vol. 118, Issue 6, pp. 1401-1411, (2016) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." in: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Kedia, Ückert, Oelke, Sonnenberg, Sohn, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human male urethra." in: Urology, Vol. 85, Issue 4, pp. 964.e1-6, (2015) (PubMed).

Yougbaré, Boire, Roy, Lugnier, Rouseau: "NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production." in: Canadian journal of physiology and pharmacology, Vol. 91, Issue 5, pp. 353-61, (2014) (PubMed).

Guo, Lin, Zhao, Zhang, Wei, Wang, Wang: "Etazolate abrogates the lipopolysaccharide (LPS)-induced downregulation of the cAMP/pCREB/BDNF signaling, neuroinflammatory response and depressive-like behavior in mice." in: Neuroscience, Vol. 263, pp. 1-14, (2014) (PubMed).

Zhai, Chang, Wei, Liu, Leblais, Fischmeister, Ji: "Phosphodiesterase types 3 and 4 regulate the phasic contraction of neonatal rat bladder smooth myocytes via distinct mechanisms." in: Cellular signalling, Vol. 26, Issue 5, pp. 1001-10, (2014) (PubMed).

Vang, Housley, Dong, Basole, Ben-Sasson, Kream, Epstein, Clark, Brocke: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." in: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).

Ückert, Waldkirch, Sonnenberg, Sandner, Kuczyk, Hedlund: "Expression and distribution of phosphodiesterase isoenzymes in the human seminal vesicles." in: The journal of sexual medicine, Vol. 8, Issue 11, pp. 3058-65, (2012) (PubMed).

Waldkirch, Ückert, Sigl, Satzger, Geismar, Langnäse, Richter, Sohn, Kuczyk, Hedlund: "Expression of cyclic AMP-dependent protein kinase isoforms in human cavernous arteries: functional significance and relation to phosphodiesterase type 4." in: The journal of sexual medicine, Vol. 7, Issue 6, pp. 2104-2111, (2011) (PubMed).

Abusnina, Alhosin, Keravis, Muller, Fuhrmann, Bronner, Lugnier: "Down-regulation of cyclic nucleotide phosphodiesterase PDE1A is the key event of p73 and UHRF1 deregulation in thymoquinone-induced acute lymphoblastic leukemia cell apoptosis." in: Cellular signalling, Vol. 23, Issue 1, pp. 152-60, (2011) (PubMed).

Yougbare, Morin, Senouvo, Sirois, Albadine, Lugnier, Rousseau: "NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 301, Issue 4, pp. L441-50, (2011) (PubMed).

Vedin, Eriksson, Berghard: "Organization of the chemosensory neuroepithelium of the vomeronasal organ of the Scandinavian moose Alces alces." in: Brain research, Vol. 1306, pp. 53-61, (2010) (PubMed).

Fatemi, Folsom, Reutiman, Braun, Lavergne: "Levels of phosphodiesterase 4A and 4B are altered by chronic treatment with psychotropic medications in rat frontal cortex." in: Synapse (New York, N.Y.), Vol. 64, Issue 7, pp. 550-5, (2010) (PubMed).

Waldkirch, Uckert, Sigl, Langnaese, Richter, Stief, Kuczyk, Hedlund: "Expression of cAMP-dependent protein kinase isoforms in the human prostate: functional significance and relation to PDE4." in: Urology, Vol. 76, Issue 2, pp. 515.e8-14, (2010) (PubMed).

Fatemi, Reutiman, Folsom, Lee: "Phosphodiesterase-4A expression is reduced in cerebella of patients with bipolar disorder." in: Psychiatric genetics, Vol. 18, Issue 6, pp. 282-8, (2009) (PubMed).

Hörnberg, Gussing, Berghard, Bohm: "Retinoic acid selectively inhibits death of basal vomeronasal neurons during late stage of neural circuit formation." in: Journal of neurochemistry, Vol. 110, Issue 4, pp. 1263-75, (2009) (PubMed).

Liu, Fraser, Koos: "Grueneberg ganglion olfactory subsystem employs a cGMP signaling pathway." in: The Journal of comparative neurology, Vol. 516, Issue 1, pp. 36-48, (2009) (PubMed).

Zhang, Huang, Masood, Stolinski, Li, Zhang, Dlaboga, Jin, Conti, ODonnell: "Anxiogenic-like behavioral phenotype of mice deficient in phosphodiesterase 4B (PDE4B)." in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Vol. 33, Issue 7, pp. 1611-23, (2008) (PubMed).

Braun, Reutiman, Lee, Folsom, Fatemi: "Expression of phosphodiesterase 4 is altered in the brains of subjects with autism." in: Neuroreport, Vol. 18, Issue 17, pp. 1841-4, (2008) (PubMed).

Details zu PDE4A

Target: PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))

Andere Bezeichnung: PDE4A

UniProt: P27815

Pathways: cAMP Metabolic Process