PDE4A Antikörper

Produktnummer ABIN2747099

Produktdetails anti-PDE4A Antikörper

Target: PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))

Reaktivität: Human, Maus, Ratte, Huhn, Affe

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE4A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Confocal Microscopy (CM)

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide common to most PDE4 subtypes: PDE4A, PDE4D, PDE4B

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.62 μg/μL

Referenzen für anti-PDE4A Antikörper (ABIN2747099)

Lee, Shin, Hong: "The Regulatory Role of Rolipram on Inflammatory Mediators and Cholinergic/Adrenergic Stimulation-Induced Signals in Isolated Primary Mouse Submandibular Gland Cells." in: Mediators of inflammation, Vol. 2016, pp. 3745961, (2017) (PubMed).

Wang, Zhang, Liu, Zhao, Zhang, Yuan, An, Li, Wang, Qin, Wilson, ODonnell, Zhang, Li: "RNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects." in: British journal of pharmacology, Vol. 168, Issue 4, pp. 1001-14, (2013) (PubMed).

Castiglione, Bergamini, Russo, La Croce, Castagna, Colciago, Salonia, Rigatti, Montorsi, Hedlund: "Inhibition of phosphodiesterase 4 enhances clitoral and vaginal blood flow responses to dorsal clitoral nerve stimulation or PGE1 in anesthetized female rats." in: The journal of sexual medicine, Vol. 10, Issue 4, pp. 939-50, (2013) (PubMed).

Muzaffar, Jeremy, Angelini, Shukla: "NADPH oxidase 4 mediates upregulation of type 4 phosphodiesterases in human endothelial cells." in: Journal of cellular physiology, Vol. 227, Issue 5, pp. 1941-50, (2012) (PubMed).

Li, Cheng, Huang, Conti, Wilson, ODonnell, Zhang: "Phosphodiesterase-4D knock-out and RNA interference-mediated knock-down enhance memory and increase hippocampal neurogenesis via increased cAMP signaling." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 1, pp. 172-83, (2011) (PubMed).

Yagi, Tada, Kitazato, Tamura, Satomi, Nagahiro: "Ibudilast inhibits cerebral aneurysms by down-regulating inflammation-related molecules in the vascular wall of rats." in: Neurosurgery, Vol. 66, Issue 3, pp. 551-9; discussion 559, (2010) (PubMed).

Dodd-o, Hristopoulos, Kibler, Gutkowska, Mukaddam-Daher, Gonzalez, Welsh-Servinsky, Pearse: "The role of natriuretic peptide receptor-A signaling in unilateral lung ischemia-reperfusion injury in the intact mouse." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 294, Issue 4, pp. L714-23, (2008) (PubMed).

Uckert, Oelke, Stief, Andersson, Jonas, Hedlund: "Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate." in: European urology, Vol. 49, Issue 4, pp. 740-5, (2007) (PubMed).

Ückert, Oelke, Albrecht, Stief, Jonas, Hedlund: "Immunohistochemical description of cyclic nucleotide phosphodiesterase (PDE) isoenzymes in the human labia minora." in: The journal of sexual medicine, Vol. 4, Issue 3, pp. 602-608, (2007) (PubMed).

Creighton, Zhu, Alexeyev, Stevens: "Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation." in: Journal of cell science, Vol. 121, Issue Pt 1, pp. 110-9, (2007) (PubMed).

Oelke, Hedlund, Albrecht, Ellinghaus, Stief, Jonas, Andersson, Uckert: "Expression of cAMP and cGMP-phosphodiesterase isoenzymes 3, 4, and 5 in the human clitoris: immunohistochemical and molecular biology study." in: Urology, Vol. 67, Issue 5, pp. 1111-6, (2006) (PubMed).

Uckert, Hedlund, Waldkirch, Sohn, Jonas, Andersson, Stief: "Interactions between cGMP- and cAMP-pathways are involved in the regulation of penile smooth muscle tone." in: World journal of urology, Vol. 22, Issue 4, pp. 261-6, (2005) (PubMed).

Uckert, Oelke, Waldkirch, Stief, Albrecht, Tröger, Jonas, Andersson, Hedlund: "Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves." in: Urology, Vol. 65, Issue 3, pp. 604-10, (2005) (PubMed).

Details zu PDE4A

Target: PDE4A (phosphodiesterase 4A, CAMP-Specific (PDE4A))

Andere Bezeichnung: PDE4 (PDE4A Produkte)

Pathways: cAMP Metabolic Process