DLL4 Antikörper (delta-Like 4)

Details for Product anti-DLL4 Antibody No. ABIN2749212, Anbieter: Anmelden zum Anzeigen
Antigen
  • hdelta2
  • Delta4
  • si:ch211-244p18.5
  • zgc:136596
  • delta like canonical Notch ligand 4
  • delta-like 4 (Drosophila)
  • DLL4
  • Dll4
  • dll4
Reaktivität
Human
190
87
47
4
4
4
3
3
3
2
2
1
1
1
Wirt
Maus
93
87
42
13
7
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser DLL4 Antikörper ist unkonjugiert
12
8
8
7
6
6
6
6
5
4
4
4
4
4
4
4
3
3
3
2
1
1
1
1
1
1
1
1
1
Applikation
Functional Studies (Func), Flow Cytometry (FACS)
137
98
84
54
33
13
8
8
6
5
5
4
2
2
2
2
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen recombinant soluble human DLL4
Klon MHD4-46
Isotyp IgG1
Spezifität The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.
Reinigung Purified from cell culture supernatant by protein-A affinity chromatography.
Reinheit > 95 % (by SDS-PAGE)
Plasmids, Primers & others Plasmide, Primers & weitere DLL4 products on genomics-online (e.g. as negative or positive controls)
Antigen delta-Like 4 (DLL4)
Andere Bezeichnung DLL4 (DLL4 Antibody Abstract)
Hintergrund DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.
Gen-ID 54567
Pathways Notch Signalweg
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Lagerung 4 °C
Informationen zur Lagerung Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Produkt verwendet in: Sekine, Koyanagi, Koyama, Hozumi, Chiba, Yagita: "Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes." in: Arthritis research & therapy, Vol. 14, Issue 2, pp. R45, 2012 (PubMed).

Oishi, Sunamura, Egawa, Motoi, Unno, Furukawa, Habib, Yagita: "Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer." in: Pancreas, Vol. 39, Issue 6, pp. 897-903, 2010 (PubMed).

Yamanda, Ebihara, Asada, Okazaki, Niu, Ebihara, Koyanagi, Yamaguchi, Yagita, Arai: "Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade." in: Blood, Vol. 113, Issue 15, pp. 3631-9, 2009 (PubMed).

Haben Sie etwas anderes gesucht?