DLL4 Antikörper

Produktnummer ABIN2749212

Der Maus Monoklonal Anti-DLL4-Antikörper wurde für FACS und Func validiert. Er ist geeignet, DLL4 in Proben von Human zu detektieren. Es sind 3+ Publikationen verfügbar.

Kurzübersicht für DLL4 Antikörper (ABIN2749212)

Target: DLL4 (delta-Like 4 (DLL4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DLL4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Functional Studies (Func)

Klon: MHD4-46

Produktdetails anti-DLL4 Antikörper

Verwendungszweck: Anti-DLL4 Purified Low Endotoxin

Spezifität: The mouse monoclonal antibody MHD4-46 recognizes the extracellular domain of DLL4 (Delta-like ligand 4), a type I transmembrane protein which plays an important role in vascular development.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Endotoxin-Niveau: Endotoxin level is less than 0.01 EU/µg of the protein, as determined by the LAL test.

Immunogen: recombinant soluble human DLL4

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Functional application: Blocking.
Flow cytometry: Recommended dilution: 1-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-DLL4 Antikörper (ABIN2749212)

Sekine, Koyanagi, Koyama, Hozumi, Chiba, Yagita: "Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes." in: Arthritis research & therapy, Vol. 14, Issue 2, pp. R45, (2012) (PubMed).

Oishi, Sunamura, Egawa, Motoi, Unno, Furukawa, Habib, Yagita: "Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer." in: Pancreas, Vol. 39, Issue 6, pp. 897-903, (2010) (PubMed).

Yamanda, Ebihara, Asada, Okazaki, Niu, Ebihara, Koyanagi, Yamaguchi, Yagita, Arai: "Role of ephrinB2 in nonproductive angiogenesis induced by Delta-like 4 blockade." in: Blood, Vol. 113, Issue 15, pp. 3631-9, (2009) (PubMed).

Details zu DLL4

Target: DLL4 (delta-Like 4 (DLL4))

Andere Bezeichnung: DLL4

Hintergrund: Delta like canonical Notch ligand 4,DLL4 (Delta-like 4) is one of five ligands of Notch receptors. It interacts with Notch1 and Notch4. DLL4 is up-regulated at sites of physiologic and pathologic angiogenesis, whereas its expression is low in most adult normal tissues. It is also highly expressed in human clear-cell renal carcinomas, bladder cancers, and breast cancers. Blocking the DLL4-Notch interaction seems to be a promissing therapeutic approach.,Delta like ligand 4, AOS6, canonical Notch ligand 4

Gen-ID: 54567

UniProt: Q9NR61

Pathways: Notch Signalweg