PVRL2 Antikörper (PE)

Produktnummer ABIN2749199

Produktdetails anti-PVRL2 Antikörper (PE)

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PVRL2 Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Verwendungszweck: Anti-Hu CD112 PE

Spezifität: The mouse monoclonal antibody R2.525 recognizes an extracellular epitope on CD112, a type I transmembrane glycoprotein expressed by myelomonocytic and megakaryocytic cells, and by CD34+ hematopoietic progenitors.

Kreuzreaktivität (Details): Human

Aufreinigung: Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

Immunogen: NIH/3T3 cells transfected with human Nectin-2

Klon: R2-525

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 10⁶ cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Referenzen für anti-PVRL2 Antikörper (PE) (ABIN2749199)

Hou, Ge, Zheng, Wei, Sun, Tian: "CD226 protein is involved in immune synapse formation and triggers Natural Killer (NK) cell activation via its first extracellular domain." in: The Journal of biological chemistry, Vol. 289, Issue 10, pp. 6969-77, (2014) (PubMed).

Enqvist, Nilsonne, Hammarfjord, Wallin, Björkström, Björnstedt, Hjerpe, Ljunggren, Dobra, Malmberg, Carlsten: "Selenite induces posttranscriptional blockade of HLA-E expression and sensitizes tumor cells to CD94/NKG2A-positive NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 7, pp. 3546-54, (2011) (PubMed).

Details zu PVRL2

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Andere Bezeichnung: CD112 (PVRL2 Produkte)

Hintergrund: Nectin cell adhesion molecule 2,CD112, also known as nectin-2, is a transmembrane glycoprotein involved in organization of adherens junctions. It also serves as a target molecule for entry of certain strains of herpes simplex virus (HSV) and pseudorabies virus (PRV). It is homologous to CD155, which serves as a target molecule for polio virus. CD112 seems to play a role in neural tube formation, with N-cadherin. Inside the cell, CD112 is connected with actin cytoskeleton through afadin. Variations in the CD112 gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.,NECTIN2, HVEB, PRR2, PVRL2, PVRR2

Gen-ID: 5819

UniProt: Q92692

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization