CD40 Ligand Antikörper

Produktnummer ABIN2749183

Zitiert in 5+ Publikationen. Der Maus Monoklonal anti-CD40 Ligand Antikörper (Klon 24-31) (ABIN2749183) detektiert spezifisch CD40 Ligand in FACS und ICC. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Non-Human Primate.

Kurzübersicht für CD40 Ligand Antikörper (ABIN2749183)

Target: CD40 Ligand (CD40LG)

Reaktivität: Human, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD40 Ligand Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: 24-31

Produktdetails anti-CD40 Ligand Antikörper

Verwendungszweck: Anti-Hu CD154 Purified

Kreuzreaktivität (Details): Human, Non-Human Primates

Produktmerkmale: The mouse monoclonal antibody 24-31 detects an extracellular epitope of CD154 / CD40L (CD40-ligand), a 39 kDa cell surface type II glycoprotein expressed predominantly on activated CD4+ lymphocytes.

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Immunogen: human CD154 fusion protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 2-6 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-CD40 Ligand Antikörper (ABIN2749183)

Brams, Black, Padlan, Hariharan, Leonard, Chambers-Slater, Noelle, Newman: "A humanized anti-human CD154 monoclonal antibody blocks CD154-CD40 mediated human B cell activation." in: International immunopharmacology, Vol. 1, Issue 2, pp. 277-94, (2001) (PubMed).

Berner, Wolf, Hummel, Müller, Reuss-Borst: "Increased expression of CD40 ligand (CD154) on CD4+ T cells as a marker of disease activity in rheumatoid arthritis." in: Annals of the rheumatic diseases, Vol. 59, Issue 3, pp. 190-5, (2000) (PubMed).

Barnhart, Ford, Bhushan, Song, Covey: "A polymorphic CD40 ligand (CD154) molecule mediates CD40-dependent signalling but interferes with the ability of soluble CD40 to functionally block CD154:CD40 interactions." in: Immunology, Vol. 99, Issue 1, pp. 54-61, (2000) (PubMed).

Grammer, McFarland, Heaney, Darnell, Lipsky: "Expression, regulation, and function of B cell-expressed CD154 in germinal centers." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 8, pp. 4150-9, (1999) (PubMed).

Kornbluth, Kee, Richman: "CD40 ligand (CD154) stimulation of macrophages to produce HIV-1-suppressive beta-chemokines." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 9, pp. 5205-10, (1998) (PubMed).

Details zu CD40 Ligand

Target: CD40 Ligand (CD40LG)

Andere Bezeichnung: CD154

Hintergrund: CD40 ligand,CD154 / CD40L (CD40 ligand) is a member of the tumor necrosis factor family, and is expressed primarily on activated CD4+ lymphocytes, but also on mast cells, basophils, eosinophils and human dendritic cells. Its counter-receptor CD40 is expressed on antigen presenting cells, including dendritic cells, macrophages, and B cells, and also on fibroblasts. Triggering of CD40 by CD40L causes maturation of dendritic cells and upregulation of antigen presentation in functions of the MHC and costimulatory molecules. CD40L also functions as a direct stimulating factor for T cells. CD40L plays also roles e.g. in antibody class switching and modulation of apoptosis in the germinal center.,CD40L, CD40 ligand, TNFSF5, Ly62, gp39, T-BAM

Gen-ID: 21947

UniProt: P27548

Pathways: NF-kappaB Signalweg, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints