Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

ROR2 Antikörper (AA 900-950)

ROR2 Reaktivität: Human, Ratte, Maus WB, IHC, ELISA, IP Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN2747364
  • Target Alle ROR2 Antikörper anzeigen
    ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))
    Bindungsspezifität
    • 12
    • 10
    • 8
    • 7
    • 5
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 900-950
    Reaktivität
    • 74
    • 26
    • 24
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 68
    • 9
    Kaninchen
    Klonalität
    • 66
    • 11
    Polyklonal
    Konjugat
    • 37
    • 6
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ROR2 Antikörper ist unkonjugiert
    Applikation
    • 51
    • 34
    • 29
    • 16
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)
    Spezifität
    The antibody labels a strong band of ROR2 at 113 kDa in ABIN1741697 samples and in other cancer cell lines.
    Kreuzreaktivität
    Maus, Ratte (Rattus)
    Kreuzreaktivität (Details)
    Does not cross react to any other cellular protein.
    Produktmerkmale
    ROR2- selective antibodies were generated against a peptide taken the C-terminal region. The ROR2-selective antibodies are affinity purified on an immobilized antigen based affinity matrix, the isolated antibodies were then stabilized in antibody stabilization buffer for long-term storage. The anti- ROR1-selective antibodies are fully characterized for applications in western blotting and ELISA at the recommended dilutions. The supplier provides ROR2 Western blot positive control samples in ready-to-use SDS-PAGE sample buffer. Limited quantities of antigenic blocking peptide for ROR2 antibody is also available, please inquire before ordering.
    Aufreinigung
    Affinity Purified
    Immunogen
    Synthetic peptide taken within amino acid region 900-950 on human ROR2 protein.
    Isotyp
    IgG
    Top Product
    Discover our top product ROR2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Kommentare

    Synonyms: neurotrophic tyrosine kinase receptor-related 2/ NTRKR2

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.55-0.75 μg/μL
    Handhabung
    Working solutions of antibodies in buffer should be filtered through 0.45 μm filter after every use for long-term storage.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For long-term storage of keep at -20 °C. We don't recommend storage of very dilute antibody solutions unless they are prepared in specially formulated multi use antibody dilution buffer.
  • Target
    ROR2 (Receptor Tyrosine Kinase-Like Orphan Receptor 2 (ROR2))
    Andere Bezeichnung
    ROR2 (ROR2 Produkte)
    Synonyme
    BDB antikoerper, BDB1 antikoerper, NTRKR2 antikoerper, Ntrkr2 antikoerper, mRor2 antikoerper, ROR2 antikoerper, bdb antikoerper, bdb1 antikoerper, Xror2 antikoerper, ntrkr2 antikoerper, MGC97773 antikoerper, LOC100219935 antikoerper, ror2 antikoerper, xror2 antikoerper, receptor tyrosine kinase like orphan receptor 2 antikoerper, receptor tyrosine kinase-like orphan receptor 2 antikoerper, receptor tyrosine kinase like orphan receptor 2 L homeolog antikoerper, ROR2 antikoerper, Ror2 antikoerper, ror2 antikoerper, ror2.L antikoerper
    Hintergrund
    The Receptor tyrosine kinase-like Orphan Receptor (ROR) proteins are conserved tyrosine kinase receptors that pattern tissues and organs during embryonic development and in adulthood. ROR family proteins are ligand-dependent transcription factors that are required for skeletal and neuronal development, and modulate cell migration, cell polarity, and convergent extension. RORs act as Wnt receptors signaling via novel non-canonical Wnt pathways mediated by the adapter protein disheveled and the non-receptor tyrosine kinase Src. RORs can either activate or repress Wnt target expression depending on the cellular context and can also modulate signal transduction by sequestering Wnt ligands away from their signaling receptors.The mammalian ROR family of receptor tyrosine kinases consists of two structurally related proteins, ROR1 and ROR2. ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass trans membrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 also interacts with canonical Wnt1 and Wnt3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactylic type B1, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails or the autosomal recessive skeletal disorder, Robinow syndrome which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. ROR2 possesses dual roles in tumorigenesis as a tumor suppressor or activator depending on tumor type. ROR2 expression in primary human Renal Cell Carcinoma (RCC) tumors showed a significant correlation with several Wnt signaling genes, including the classical feedback target gene Axin2.
    NCBI Accession
    NP_004551
    UniProt
    Q01974
    Pathways
    RTK Signalweg, WNT Signalweg
Sie sind hier:
Kundenservice