GFAP Antikörper (AA 417-432)

Produktnummer ABIN2741090

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GFAP in WB, IHC und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Maus, Kaninchen, Pferd, Affe und Gibbon.

Kurzübersicht für GFAP Antikörper (AA 417-432) (ABIN2741090)

Target: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Reaktivität: Human, Ratte, Maus, Kaninchen, Pferd, Affe, Gibbon

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFAP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-GFAP Antikörper

Bindungsspezifität: AA 417-432

Spezifität: Human GFAP

Aufreinigung: Immunoaffinity purified

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human GFAP (417-432aa DGEVIKESKQEHKDVM). Percent identity by BLAST analysis: Human, Gibbon, Galago, Marmoset, Rat, Cat, Rabbit, Horse (100%), Pig, Dog (94%), Mouse (88%), Opossum (81%).

Type of Immunogen: Synthetic peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Approved: IHC, IHC-P (0.5 - 1 μg/mL), WB (0.5 - 1 μg/mL)

Usage: Glial fibrillary acidic protein is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. Expression is also seen in rat kidney glomeruli and peritubular fibroblasts, leydig cells of testis, skin keratinocytes, osteocytes of bones, chondrocytes of epiglottis, bronchus, and stellate-shaped cells of the pancreas and liver. Its expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination. The protein has also been shown to play a role in mitosis by adjusting the filament network present in the cell. During mitosis, there is an increase in the amount of phosphorylated GFAP, and a movement of this modified protein to the cleavage furrow.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Sterile distilled water

Konzentration: Lot specific

Buffer: Lyophilized from PBS, 2.5 % BSA, 0.025 % sodium azide/thimerosal.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for 1 month or -20°C for longer. Avoid freeze/thaw cycles.

Details zu GFAP

Target: GFAP (Glial Fibrillary Acidic Protein (GFAP))

Andere Bezeichnung: GFAP

Hintergrund: Name/Gene ID: GFAP

Synonyms: GFAP

Gen-ID: 2670