GALE Antikörper

Produktnummer ABIN2721595

Der Maus Monoklonal anti-GALE Antikörper wird verwendet zum Nachweis von GALE in Proben von Human, Ratte, Hund und Affe. Er wurde validiert für WB und IHC.

Kurzübersicht für GALE Antikörper (ABIN2721595)

Target: GALE (UDP-Galactose-4-Epimerase (GALE))

Reaktivität: Human, Ratte, Hund, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GALE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: 1C4

Produktdetails anti-GALE Antikörper

Produktmerkmale: Homo sapiens UDP-galactose-4-epimerase (GALE), transcript variant 1

Aufreinigung: Purified from mouse ascites fluids by affinity chromatography

Immunogen: Full length human recombinant protein of human GALE (NP_000394) produced in HEK293T cell.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB 1:500~2000, IHC 1:150,

Kommentare:

The concentration of the product may vary between diferrent lots.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5-1.0 mg/mL

Buffer: PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu GALE

Target: GALE (UDP-Galactose-4-Epimerase (GALE))

Andere Bezeichnung: GALE

Hintergrund: This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified.

Molekulargewicht: 38.1 kDa

Gen-ID: 2582

NCBI Accession: NM_000403

HGNC: 2582

Pathways: Response to Water Deprivation, Cellular Glucan Metabolic Process