WAS
Reaktivität: Human
WB
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
ELISA: 1/5000-1/10000. Western Blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
IMD2 antikoerper, SCNX antikoerper, THC antikoerper, THC1 antikoerper, WASP antikoerper, U42471 antikoerper, WASp antikoerper, Wasp antikoerper, imd2 antikoerper, thc antikoerper, thc1 antikoerper, was antikoerper, wasp antikoerper, wu:fk81c08 antikoerper, zgc:64164 antikoerper, Wiskott-Aldrich syndrome antikoerper, neural Wiskott-Aldrich syndrome protein antikoerper, wiskott-aldrich syndrome protein antikoerper, Wiskott-Aldrich syndrome L homeolog antikoerper, Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b antikoerper, WAS antikoerper, LOC5578888 antikoerper, CpipJ_CPIJ006699 antikoerper, Was antikoerper, was.L antikoerper, wasb antikoerper
Hintergrund
The Wiskott-Aldrich syndrome (WAS) is a disorder that results from a monogenic defect that has been mapped to the short arm of the X chromosome at Xp11.23. WAS is characterized by thrombocytopenia, eczema, defects in cell-mediated and humoral immunity and a propensity for lymphoproliferative disease. The gene that is mutated in the syndrome encodes a 53 kDa proline-rich protein of unknown function designated WAS protein (WASP). A clue to WASP function came from the observation that T cells from affected males had an irregular cellular morphology and a disarrayed cytoskeleton suggesting the involvement of WASP in cytoskeletal organization. Close examination of the WASP sequence revealed a putative Cdc42/Rac interacting domain, homologous with those found in PAK65 and ACK. Subsequent investigation has shown WASP to be a true downstream effector of Cdc42.Synonyms: WASp, Wiskott-Aldrich syndrome protein