WASP Antikörper (AA 205-234)

Produktnummer ABIN1881997

Produktdetails anti-WASP Antikörper

Target: WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))

Bindungsspezifität: AA 205-234

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser WASP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This WAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human WAS.

Klon: RB40707

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-WASP Antikörper (ABIN1881997)

Almgren, Garamus, Nordstierna, Luc-Blin, Stébé: "Nonideal mixed micelles of fluorinated and hydrogenous surfactants in aqueous solution. NMR and SANS studies of anionic and nonionic systems." in: Langmuir : the ACS journal of surfaces and colloids, Vol. 26, Issue 8, pp. 5355-63, (2010) (PubMed).

Dovas, Gevrey, Grossi, Park, Abou-Kheir, Cox: "Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages." in: Journal of cell science, Vol. 122, Issue Pt 21, pp. 3873-82, (2009) (PubMed).

Ameratunga, Woon: "Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country." in: The New Zealand medical journal, Vol. 122, Issue 1304, pp. 46-53, (2009) (PubMed).

Details zu WASP

Target: WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))

Andere Bezeichnung: WAS (WAS Produkte)

Synonyme: IMD2 antikoerper, SCNX antikoerper, THC antikoerper, THC1 antikoerper, WASP antikoerper, U42471 antikoerper, WASp antikoerper, Wasp antikoerper, imd2 antikoerper, thc antikoerper, thc1 antikoerper, was antikoerper, wasp antikoerper, wu:fk81c08 antikoerper, zgc:64164 antikoerper, Wiskott-Aldrich syndrome antikoerper, neural Wiskott-Aldrich syndrome protein antikoerper, wiskott-aldrich syndrome protein antikoerper, Wiskott-Aldrich syndrome L homeolog antikoerper, Wiskott-Aldrich syndrome (eczema-thrombocytopenia) b antikoerper, WAS antikoerper, LOC5578888 antikoerper, CpipJ_CPIJ006699 antikoerper, Was antikoerper, was.L antikoerper, wasb antikoerper

Hintergrund: The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

Molekulargewicht: 52913

NCBI Accession: NP_000368

UniProt: P42768