PDE4D Antikörper

Produktnummer ABIN272057

Produktdetails anti-PDE4D Antikörper

Target: PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE4D Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: Thhis antibody detects endogenous levels of PDE4D protein. (region surrounding His47)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 10000approx. 1: 20000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu PDE4D

Target: PDE4D (phosphodiesterase 4D, cAMP-Specific (PDE4D))

Andere Bezeichnung: PDE4D (PDE4D Produkte)

Synonyme: ACRDYS2 antikoerper, DPDE3 antikoerper, HSPDE4D antikoerper, PDE43 antikoerper, PDE4DN2 antikoerper, STRK1 antikoerper, CMYA2 antikoerper, MMGL antikoerper, 9630011N22Rik antikoerper, Dpde3 antikoerper, 4732458A06Rik antikoerper, 9430063L05Rik antikoerper, C87016 antikoerper, D130016K21Rik antikoerper, D3Bwg1078e antikoerper, Usmg4 antikoerper, mKIAA0454 antikoerper, si:dkey-190g11.2 antikoerper, phosphodiesterase 4D antikoerper, phosphodiesterase 4D interacting protein antikoerper, phosphodiesterase 4D, cAMP specific antikoerper, phosphodiesterase 4D, cAMP-specific antikoerper, phosphodiesterase 4D interacting protein (myomegalin) antikoerper, PDE4D antikoerper, PDE4DIP antikoerper, pde4d antikoerper, Pde4dip antikoerper, Pde4d antikoerper

Hintergrund: Phosphodiesterases (PDE) hydrolyze cAMP to 5'AMP and thus play a critical role in the regulation of intracellular cAMP. Division of the PDE superfamily by sequence homology and enzymatic properties yields 11 PDE families. A unique upstream conserved region (UCR) characterizes the PDE4 family. Four separate genes (A-D) encode the PDE4 enzymes, and alternative splicing generates short or long isoforms of each gene. Long PDE4 isoforms contain both UCR1 and UCR2 while short PDE4 isoforms possess only UCR2. Both UCR domains are necessary for dimerization of PDE4 isoforms. The human PDE4D gene maps to chromosome 5q12. The splice variants include isoforms PDE4D1-6.Synonyms: 5'-cyclic phosphodiesterase 4D, DPDE3, EC=3.1.4.17, PDE43, PDE4D, cAMP-specific 3'

Molekulargewicht: approx. 88 kDa

Gen-ID: 5144

NCBI Accession: NP_001098101

UniProt: Q08499

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling