XPA Antikörper

Produktnummer ABIN271978

Produktdetails anti-XPA Antikörper

Target: XPA (Xeroderma Pigmentosum, Complementation Group A (XPA))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XPA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of XPA protein. (region surrounding His244)

Kreuzreaktivität (Details): Species reactivity (tested):Human and Mouse.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/5000approx. 1/10000. Western blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu XPA

Target: XPA (Xeroderma Pigmentosum, Complementation Group A (XPA))

Andere Bezeichnung: XPA / XPAC (XPA Produkte)

Synonyme: CG6358 antikoerper, DhR14 antikoerper, DhXPA antikoerper, DmXPA antikoerper, Dmel\\CG6358 antikoerper, Dxpa antikoerper, EG:EG0007.8 antikoerper, XPAC antikoerper, XPA_DROME antikoerper, Xpa antikoerper, dmXPA antikoerper, dxpa antikoerper, XP1 antikoerper, AI573865 antikoerper, Xpac antikoerper, xpac antikoerper, xxpa antikoerper, Xeroderma pigmentosum group A-like antikoerper, XPA, DNA damage recognition and repair factor antikoerper, xeroderma pigmentosum, complementation group A antikoerper, xeroderma pigmentosum, complementation group A L homeolog antikoerper, Xpac antikoerper, XPA antikoerper, Xpa antikoerper, xpa.L antikoerper

Hintergrund: Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer due to deficiencies in the DNA repair enzymes. The most frequent mutations are found in the XP genes of group A through G and group V, which encode nucleotide excision repair proteins. The XPA gene encodes a 31 kDa zinc metalloprotein that preferentially binds to DNA damaged by UV radiation and chemical carcinogens and is required for the incision step during nucleotide excision repair. The XPB and XPD genes encode DNA helicases involved in several DNA metabolic pathways, including DNA repair and transcription, and the XPG gene product is an endonuclease that cuts on the 3' side of a DNA lesion during nucleotide excision repair. Molecular defects in the XP variant (XPV) group maintain normal excision repair, yet they result in a substantial reduction in the ability to synthesize intact daughter DNA strands during DNA replication following DNA damage.Synonyms: DNA repair protein complementing XP-A cells, Xeroderma pigmentosum group A-complementing protein

Molekulargewicht: approx. 33, 40 kDa

Gen-ID: 7507

NCBI Accession: NP_000371

UniProt: P23025

Pathways: DNA Reparatur