SUMO1 Antikörper

Produktnummer ABIN271962

Produktdetails anti-SUMO1 Antikörper

Target: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUMO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Sumo1 protein. (region surrounding Ser2)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Reinheit: > 95 % pure by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: ELISA: 1: 20000approx. 1: 40000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200. IF: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: DO NOT FREEZE!

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu SUMO1

Target: SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))

Andere Bezeichnung: SUMO1 (SUMO1 Produkte)

Synonyme: DAP1 antikoerper, GMP1 antikoerper, OFC10 antikoerper, PIC1 antikoerper, SENP2 antikoerper, SMT3 antikoerper, SMT3C antikoerper, SMT3H3 antikoerper, UBL1 antikoerper, hm:zeh0670 antikoerper, wu:fb74c02 antikoerper, wu:fd12c02 antikoerper, zgc:65934 antikoerper, zgc:85634 antikoerper, SUMO1 antikoerper, dap1 antikoerper, gmp1 antikoerper, ofc10 antikoerper, pic1 antikoerper, senp2 antikoerper, smt3 antikoerper, smt3c antikoerper, sumo-1 antikoerper, sumo1 antikoerper, ubl1 antikoerper, xsumo-1 antikoerper, xsumo1 antikoerper, ARABIDOPSIS THALIANA SMALL UBIQUITIN-LIKE MODIFIER 1 antikoerper, ATSUMO1 antikoerper, F10M23.180 antikoerper, F10M23_180 antikoerper, SMALL UBIQUITIN-LIKE MODIFIER 1 antikoerper, SUM1 antikoerper, SUMO 1 antikoerper, small ubiquitin-like modifier 1 antikoerper, pigSUMO1 antikoerper, SENTRIN antikoerper, SMTP3 antikoerper, SUMO-1 antikoerper, Smt3C antikoerper, Ubl1 antikoerper, small ubiquitin-like modifier 1 antikoerper, small ubiquitin-like modifier 1 S homeolog antikoerper, small ubiquitin-related protein 1 antikoerper, SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) antikoerper, SMT3 suppressor of mif two 3 homolog 1 (yeast) antikoerper, small ubiquitin-like modifier 1 L homeolog antikoerper, Sumo1 antikoerper, SUMO1 antikoerper, sumo1 antikoerper, sumo1.S antikoerper, sumo-1 antikoerper, sumo1.L antikoerper

Hintergrund: The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, 2, and 3, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Also, both utilize the E1, E2, and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins to a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis, and protein stability. The unconjugated SUMO-1, 2, and 3 proteins are approximately 11 kDa in mass and localize to the nuclear membrane, nuclear bodies, and cytoplasm, respectively. SUMO-1 utilizes Ubc9 for conjugation to several target proteins, which include IκBα, MDM2, p53, PML, and RanGap1. SUMO-2 and 3 contribute to a greater percentage of protein modification than does SUMO-1, and unlike SUMO-1, they can form polymeric chains. In addition, SUMO-3 regulates Amyloid β generation and may be critical in the onset or progression of Alzheimer's disease.Synonyms: GAP-modifying protein 1, GMP1, SMT3 homolog 3, SMT3C, SMT3H3, Sentrin, Small ubiquitin-related modifier 1, UBL1, Ubiquitin-homology domain protein PIC1, Ubiquitin-like protein SMT3C, Ubiquitin-like protein UBL1

Molekulargewicht: approx. 12 kDa

Gen-ID: 7341

NCBI Accession: NP_001005781

UniProt: P63165

Pathways: M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway