Acetyl-CoA Carboxylase alpha Antikörper

Produktnummer ABIN271866

Produktdetails anti-Acetyl-CoA Carboxylase alpha Antikörper

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Acetyl-CoA Carboxylase alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Acetyl-CoA Carboxylase protein. (region surrounding His74)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/5000-1/10000. Western blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Acetyl-CoA Carboxylase alpha

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Andere Bezeichnung: Acetyl-CoA Carboxylase 1 (ACACA Produkte)

Synonyme: ACAC antikoerper, ACACAD antikoerper, ACC antikoerper, ACC1 antikoerper, ACCA antikoerper, A530025K05Rik antikoerper, Acac antikoerper, Acc1 antikoerper, Gm738 antikoerper, AT-ACC1 antikoerper, EMB22 antikoerper, EMBRYO DEFECTIVE 22 antikoerper, GK antikoerper, GURKE antikoerper, PAS3 antikoerper, PASTICCINO 3 antikoerper, acetyl-CoA carboxylase 1 antikoerper, acc antikoerper, fj43d01 antikoerper, im:7138837 antikoerper, si:ch211-199d18.1 antikoerper, wu:fj43d01 antikoerper, acetyl-CoA carboxylase alpha antikoerper, acetyl-Coenzyme A carboxylase alpha antikoerper, acetyl-CoA carboxylase 1 antikoerper, ACACA antikoerper, Acaca antikoerper, ACC1 antikoerper, acaca antikoerper

Hintergrund: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the ratelimiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACC-alpha (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACC-beta (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACC-alpha is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted Serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the short-term regulatory mechanism of the enzyme. The gene encoding ACC-alpha, which maps to human chromosome 17, encodes the 265 kDa alpha form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACC-beta is homologous to that of ACC-alpha except for an additional peptide of about 150 amino acids at the N-terminus.Synonyms: ACAC, ACACA, ACC1, ACCA

Molekulargewicht: approx. 265 kDa

Gen-ID: 31

NCBI Accession: NP_942131

UniProt: Q13085

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process, Warburg Effekt