Acetyl-CoA Carboxylase alpha Antikörper

Produktnummer ABIN271865

Produktdetails anti-Acetyl-CoA Carboxylase alpha Antikörper

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Acetyl-CoA Carboxylase alpha Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of ACC1 protein.

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1000-1/5000. Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.2, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Acetyl-CoA Carboxylase alpha

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Andere Bezeichnung: Acetyl-CoA Carboxylase 1 (ACACA Produkte)

Synonyme: ACAC antikoerper, ACACAD antikoerper, ACC antikoerper, ACC1 antikoerper, ACCA antikoerper, A530025K05Rik antikoerper, Acac antikoerper, Acc1 antikoerper, Gm738 antikoerper, AT-ACC1 antikoerper, EMB22 antikoerper, EMBRYO DEFECTIVE 22 antikoerper, GK antikoerper, GURKE antikoerper, PAS3 antikoerper, PASTICCINO 3 antikoerper, acetyl-CoA carboxylase 1 antikoerper, acc antikoerper, fj43d01 antikoerper, im:7138837 antikoerper, si:ch211-199d18.1 antikoerper, wu:fj43d01 antikoerper, acetyl-CoA carboxylase alpha antikoerper, acetyl-Coenzyme A carboxylase alpha antikoerper, acetyl-CoA carboxylase 1 antikoerper, ACACA antikoerper, Acaca antikoerper, ACC1 antikoerper, acaca antikoerper

Hintergrund: Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the ratelimiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl- CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted Serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the short-term regulatory mechanism of the enzyme. The gene encoding ACCα, which maps to human chromosome 17, encodes the 265 kDa α form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of ACCα except for an additional peptide of about 150 amino acids at the N-terminus.Synonyms: ACAC, ACACA, ACC1, ACCA

Molekulargewicht: approx. 265 kDa

Gen-ID: 31

NCBI Accession: NP_942131

UniProt: Q13085

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process, Warburg Effekt