Presenilin 1 Antikörper
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- Target Alle Presenilin 1 (PSEN1) Antikörper anzeigen
- Presenilin 1 (PSEN1)
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser Presenilin 1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of Presenilin 1 protein. (region surrounding Ser28)
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human.
- Aufreinigung
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen
- Reinheit
- > 95 % pure by SDS-PAGE
- Top Product
- Discover our top product PSEN1 Primärantikörper
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- Applikationshinweise
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ELISA: 1: 40000approx. 1: 60000. WB: 1: 500approx. 1: 1000. IHC: 1: 50approx. 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1,0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- DO NOT FREEZE!
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C.
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- Target
- Presenilin 1 (PSEN1)
- Andere Bezeichnung
- Presenilin-1 (PSEN1 Produkte)
- Synonyme
- pre1 antikoerper, psen antikoerper, zfPS1 antikoerper, zf-PS1 antikoerper, ad3 antikoerper, fad antikoerper, ps1 antikoerper, s182 antikoerper, X-PS-beta antikoerper, X-PS-alpha antikoerper, AD3 antikoerper, FAD antikoerper, PS-1 antikoerper, PS1 antikoerper, S182 antikoerper, Ad3h antikoerper, presenilin 1 antikoerper, presenilin 1 L homeolog antikoerper, psen1 antikoerper, PSEN1 antikoerper, Psen1 antikoerper, psen1.L antikoerper
- Hintergrund
- A novel protein, designated Presenilin 1 (also designated S182) and mapping to the AD3 locus of chromosome 14q24.3, has been described. Mutations in the gene encoding Presenilin 1 have been found in families suffering from early-onset Alzheimer's disease. A highly related protein, designated Presenilin 2 (also designated STM2), shares 80 % amino acid sequence identity with Presenilin 1. Presenilin 1 and Presenilin 2 have similar structures and represent novel members of the seven-pass transmembrane receptor superfamily. Point mutations in the gene encoding Presenilin 2 have been found in Volga German families who suffer from an inherited form of early-onset Alzheimer's disease. Whether these proteins function as ligand-gated ion channels or G protein-coupled receptors has yet to be resolved. ALG-3, the mouse homolog of human Presenilin 2, has been cloned from the mouse liver cDNA library.Synonyms: AD3, AF3, Alzheimer Disease 3, FAD, PS-1, PS1, PSEN1, PSNL1, Presenilin 1, S182
- Molekulargewicht
- 22, 55 kDa
- Gen-ID
- 5663
- NCBI Accession
- NP_000012
- UniProt
- P49768
- Pathways
- Notch Signalweg, EGFR Signaling Pathway, Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport
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