C5AR1 Antikörper

Produktnummer ABIN2689428

Der Kaninchen Monoklonal Anti-C5AR1-Antikörper wurde für IHC (fro) und IHC (f) validiert. Er ist geeignet, C5AR1 in Proben von Human zu detektieren. Es sind 9+ Publikationen verfügbar.

Kurzübersicht für C5AR1 Antikörper (ABIN2689428)

Target: C5AR1 (Complement Component 5a Receptor 1 (C5AR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser C5AR1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

Klon: C85

Produktdetails anti-C5AR1 Antikörper

Marke: BD Pharmingen™

Produktmerkmale: The human C5a receptor (C5aR) is expressed on granulocytes, monocytes, macrophages mast cells human cell lines of myeloid origin, and certain cell types in several organs, including dendritic cells of secondary lymphoid organs, liver hepatocytes, lung bronchial and alveolar epithelial cells, lung vascular smooth muscle, endothelial cells astrocytes, microglia, and fibroblast-like cells of the brain. The C85-2506 is a rabbit monoclonal antibody generated by fusion of splenocytes from rabbits immunized with human C5aR peptides and the rabbit fusion partner 240E-1. C85-2506 staining on dendritic cells and granulocytes of human tonsil paraffin sections.

BD Pharmingen™ Purified Rabbit Anti-Human CD88 - Purified - Clone C85-2506 - Isotype Rabbit IgG - Reactivity Hu - 1 mL

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Aqueous buffered solution containing BSA, goat serum, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-C5AR1 Antikörper (ABIN2689428)

Fayyazi, Sandau, Duong, Götze, Radzun, Schweyer, Soruri, Zwirner: "C5a receptor and interleukin-6 are expressed in tissue macrophages and stimulated keratinocytes but not in pulmonary and intestinal epithelial cells." in: The American journal of pathology, Vol. 154, Issue 2, pp. 495-501, (1999) (PubMed).

Paradisis, Campbell, Barnum: "Elevated complement C5a receptor expression on neurons and glia in astrocyte-targeted interleukin-3 transgenic mice." in: Glia, Vol. 24, Issue 3, pp. 338-45, (1999) (PubMed).

Nataf, Davoust, Barnum: "Kinetics of anaphylatoxin C5a receptor expression during experimental allergic encephalomyelitis." in: Journal of neuroimmunology, Vol. 91, Issue 1-2, pp. 147-55, (1998) (PubMed).

Stahel, Frei, Eugster, Fontana, Hummel, Wetsel, Ames, Barnum: "TNF-alpha-mediated expression of the receptor for anaphylatoxin C5a on neurons in experimental Listeria meningoencephalitis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 2, pp. 861-9, (1997) (PubMed).

Morelli, Larregina, Chuluyán, Kolkowski, Fainboim: "Expression and modulation of C5a receptor (CD88) on skin dendritic cells. Chemotactic effect of C5a on skin migratory dendritic cells." in: Immunology, Vol. 89, Issue 1, pp. 126-34, (1996) (PubMed).

Füreder, Agis, Willheim, Bankl, Maier, Kishi, Müller, Czerwenka, Radaszkiewicz, Butterfield, Klappacher, Sperr, Oppermann, Lechner, Valent: "Differential expression of complement receptors on human basophils and mast cells. Evidence for mast cell heterogeneity and CD88/C5aR expression on skin mast cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 6, pp. 3152-60, (1995) (PubMed).

Haviland, McCoy, Whitehead, Akama, Molmenti, Brown, Haviland, Parks, Perlmutter, Wetsel: "Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 4, pp. 1861-9, (1995) (PubMed).

Spieker-Polet, Sethupathi, Yam, Knight: "Rabbit monoclonal antibodies: generating a fusion partner to produce rabbit-rabbit hybridomas." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 20, pp. 9348-52, (1995) (PubMed).

Wetsel: "Expression of the complement C5a anaphylatoxin receptor (C5aR) on non-myeloid cells." in: Immunology letters, Vol. 44, Issue 2-3, pp. 183-7, (1995) (PubMed).

Details zu C5AR1

Target: C5AR1 (Complement Component 5a Receptor 1 (C5AR1))

Andere Bezeichnung: CD88

Hintergrund: Synonyms: C5a Receptor

Pathways: Komplementsystem