IGF1R Antikörper

Produktnummer ABIN2689097

Produktdetails anti-IGF1R Antikörper

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IGF1R Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF), Flow Cytometry (FACS)

Marke: BD Pharmingen™

Produktmerkmale: Reacts with human insulin-like growth factor-I (IGF-I) receptor. IGF-I receptor is a glycoprotein complex composed of two extracellular α subunits and two transmembrane β subunits. The transmembrane subunits play a role in tyrosine phosphorylation of several intracellular signaling proteins. IGF-I receptor is structurally and functionally similar to insulin receptor and is expressed on a variety of human hematopoietic and non-hematopoietic cells. 3B7 antibody does not cross react with human insulin receptor, it stimulates IGF-I and IGF-II induced cell growth and activates autophosphorylation of the IGF-I receptor β subunit. Profile of Jurkat Cells analyzed on a FACScan with Biotin Goat anti-mouse Ig (Cat. No. 553999) as 2nd step, and with SAV-PE (Cat. No. 554061) as 3rd step. CD221 expression (filled) and isotype control (dash lines)

BD Pharmingen™ Purified Mouse Anti-Human CD221 - Purified - Clone 3B7 - Isotype Mouse IgG1, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Klon: 3B7

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-IGF1R Antikörper (ABIN2689097)

Kooijman, Scholtens, Rijkers, Zegers: "Differential expression of type I insulin-like growth factor receptors in different stages of human T cells." in: European journal of immunology, Vol. 25, Issue 4, pp. 931-5, (1995) (PubMed).

Xiong, Kasuya, Li, Kato, Fujita-Yamaguchi: "Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 12, pp. 5356-60, (1992) (PubMed).

Details zu IGF1R

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Andere Bezeichnung: CD221 (IGF1R Produkte)

Synonyme: CMT2N antikoerper, CD221 antikoerper, IGFIR antikoerper, IGFR antikoerper, JTK13 antikoerper, IGFIRC antikoerper, IGFR1 antikoerper, IGF-1R antikoerper, IGF1R antikoerper, DKFZp469I0618 antikoerper, igf-1r antikoerper, xIGF-1R antikoerper, xIGFR antikoerper, xigf1r antikoerper, A330103N21Rik antikoerper, D930020L01 antikoerper, hyft antikoerper, igf-ir antikoerper, IGF-IR antikoerper, IGF-IRb antikoerper, wu:fb03h06 antikoerper, IGF-IRa antikoerper, sb:eu1090 antikoerper, wu:fi20b10 antikoerper, alanyl-tRNA synthetase antikoerper, insulin like growth factor 1 receptor antikoerper, insulin-like growth factor 1 receptor antikoerper, insulin-like growth factor 1 antikoerper, insulin-like growth factor I receptor antikoerper, insulin like growth factor 1 receptor S homeolog antikoerper, insulin-like growth factor 1b receptor antikoerper, insulin-like growth factor 1a receptor antikoerper, AARS antikoerper, IGF1R antikoerper, Igf1r antikoerper, igf1r antikoerper, Igf1 antikoerper, LOC780503 antikoerper, LOC100136427 antikoerper, igf1r.S antikoerper, igf1rb antikoerper, igf1ra antikoerper

Hintergrund: Synonyms: IGF-I receptor

Pathways: RTK Signalweg, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagie