PDGFRB Antikörper

Produktnummer ABIN2688973

Zitiert in 3+ Publikationen. Der Maus Monoklonal anti-PDGFRB Antikörper (Klon 28D4) (ABIN2688973) detektiert spezifisch PDGFRB in FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für PDGFRB Antikörper (ABIN2688973)

Target: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PDGFRB Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: 28D4

Produktdetails anti-PDGFRB Antikörper

Produktmerkmale: Reacts with platelet derived growth factor (PDGF) receptor β, a 170-190 kDa single transmembrane glycoprotein expressed on fibroblasts, smooth muscle cells, glial cells and chondrocytes. PDGF receptors, α and β, are single glycoproteins with intracellular tyrosine kinase domains. They are structurally similar to M-CSF receptor and CD117 (c-kit). Their ligand, PDGF, is a mitogen for connective tissue cells and glial cells. PDGF plays a role in wound healing and acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes and neutrophils. Functional PDGF is secreted as a disulfide-linked dimer of A and B chains (PDGF-AA, PDGF-BB or PDGF-AB). Binding of divalent PDGF induces receptor dimerization with three possible forms: αα, αβ, ββ. The PDGF receptor α-subunit binds both PDGF A and B chains, whereas the receptor β-subunit binds only PDGF B chain. Both receptor subunits can stimulate mitogenic responses, only the β subunit can induce chemotaxis. 28D4 is specific for PDGFRβ and does not cross-react with PDGFRα. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature. Profile of 697 cell line analyzed by flow cytometry

BD Pharmingen™ Purified Mouse Anti-Human CD140b - Purified - Clone 28D4 - Isotype Mouse IgG2a, κ - Reactivity Hu - 0.1 mg

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Aqueous buffered solution containing ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C.

Referenzen für anti-PDGFRB Antikörper (ABIN2688973)

Ebert, Kasper, Hernberg, Friess, Büchler, Roessner, Korc, Malfertheiner: "Overexpression of platelet-derived growth factor (PDGF) B chain and type beta PDGF receptor in human chronic pancreatitis." in: Digestive diseases and sciences, Vol. 43, Issue 3, pp. 567-74, (1998) (PubMed).

Yang, Khachigian, Hicks, Chesterman, Chong: "Identification of PDGF receptors on human megakaryocytes and megakaryocytic cell lines." in: Thrombosis and haemostasis, Vol. 78, Issue 2, pp. 892-6, (1997) (PubMed).

Claesson-Welsh: "Platelet-derived growth factor receptor signals." in: The Journal of biological chemistry, Vol. 269, Issue 51, pp. 32023-6, (1995) (PubMed).

Details zu PDGFRB

Target: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Andere Bezeichnung: CD140b

Hintergrund: Synonyms: PDGF Receptor β chain

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling