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ITGAL Antikörper

ITGAL Reaktivität: Ratte FACS, IP, IHC (fro), BR Wirt: Maus Monoclonal WT-1 unconjugated
Produktnummer ABIN2688903
  • Target Alle ITGAL Antikörper anzeigen
    ITGAL (Integrin alpha-L (ITGAL))
    Reaktivität
    • 133
    • 76
    • 18
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 103
    • 61
    • 49
    • 1
    Maus
    Klonalität
    • 159
    • 54
    • 1
    Monoklonal
    Konjugat
    • 73
    • 29
    • 26
    • 21
    • 11
    • 6
    • 6
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ITGAL Antikörper ist unkonjugiert
    Applikation
    • 139
    • 54
    • 35
    • 32
    • 31
    • 27
    • 24
    • 23
    • 11
    • 8
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Blocking Reagent (BR)
    Marke
    BD Pharmingen™
    Produktmerkmale
    The WT.5 antibody reacts with the asubunit of LFA-1 (αLβ2 integrin, CD11a/CD18), a heterodimeric surface glycoprotein which is found on the majority of leukocytes, but not on peritoneal macrophages or peritoneal mast cells. LFA-1 mediates a variety of heterotypic and homotypic intercellular adhesions through interaction with ICAM-1 (CD54) and ICAM-2 (CD102). WT.1 mAb recognizes both the activated and unactivated forms of LFA-1. It inhibits the binding of LFA-1 to ICAM-1 in several in vitro assays, including binding of Concanavalin A-stimulated lymphocytes (Con A blasts) to purified ICAM-1 and Mg2+-dependent aggregation of concanavalin A-stimulated blasts. It has also been reported to inhibit leukocyte infiltration in several in vivo models of inflammation. This antibody is routinely tested by flow cytometric analysis. Other applications were tested during antibody development only or reported in the literature.

    BD Pharmingen™ Purified Mouse Anti-Rat CD11a - Purified - Clone WT.1 - Isotype Mouse IgG2a, κ - Reactivity Rat - 0.1 mg
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    PHA-stimulated rat splenocytes and rat thymic lymphoma FTL-43
    Klon
    WT-1
    Isotyp
    IgG2a kappa
    Top Product
    Discover our top product ITGAL Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C.
  • Ohta, Gotoh, Ohzato, Fukuzaki, Nishihara, Dono, Umeshita, Sakon, Yagita, Okumura, Tanaka, Kawashima, Miyasaka, Monden: "Direct antigen presentation through binding of donor intercellular adhesion molecule-1 to recipient lymphocyte function-associated antigen-1 molecules in xenograft rejection." in: Transplantation, Vol. 65, Issue 8, pp. 1094-100, (1998) (PubMed).

    Andrews, Malcontenti-Wilson, OBrien: "Expression of adhesion molecules and leukocyte recruitment into gastric mucosa following ischemia-reperfusion." in: Digestive diseases and sciences, Vol. 42, Issue 2, pp. 326-32, (1997) (PubMed).

    Watanabe, Arakawa, Fukuda, Higuchi, Kobayashi: "Role of neutrophils in a rat model of gastric ulcer recurrence caused by interleukin-1 beta." in: The American journal of pathology, Vol. 150, Issue 3, pp. 971-9, (1997) (PubMed).

    Wada, Shikata, Makino, Morioka, Hirata, Ota, Tamatani, Miyasaka, Horiuchi, Noji, Nishikawa, Myokai, Taniguchi, Kanwar, Ota: "The critical role of intercellular adhesion molecule-1 in Masugi nephritis in rats." in: Nephron, Vol. 73, Issue 2, pp. 264-72, (1996) (PubMed).

    Devine, Lightman, Greenwood: "Role of LFA-1, ICAM-1, VLA-4 and VCAM-1 in lymphocyte migration across retinal pigment epithelial monolayers in vitro." in: Immunology, Vol. 88, Issue 3, pp. 456-62, (1996) (PubMed).

    Fox, Jewell, Whitacre: "Rat peritoneal mast cells present antigen to a PPD-specific T cell line." in: Cellular immunology, Vol. 158, Issue 1, pp. 253-64, (1994) (PubMed).

    Springer: "Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm." in: Cell, Vol. 76, Issue 2, pp. 301-14, (1994) (PubMed).

    Bañuls, Alvarez, Ferrero, Zapata, Ardavin: "Cell-surface marker analysis of rat thymic dendritic cells." in: Immunology, Vol. 79, Issue 2, pp. 298-304, (1993) (PubMed).

    Yamazaki, Seko, Tamatani, Miyasaka, Yagita, Okumura, Nagai, Yazaki: "Expression of intercellular adhesion molecule-1 in rat heart with ischemia/reperfusion and limitation of infarct size by treatment with antibodies against cell adhesion molecules." in: The American journal of pathology, Vol. 143, Issue 2, pp. 410-8, (1993) (PubMed).

    Tamatani, Kotani, Miyasaka: "Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit-specific monoclonal antibodies." in: European journal of immunology, Vol. 21, Issue 3, pp. 627-33, (1991) (PubMed).

    Larson, Springer: "Structure and function of leukocyte integrins." in: Immunological reviews, Vol. 114, pp. 181-217, (1990) (PubMed).

  • Target
    ITGAL (Integrin alpha-L (ITGAL))
    Andere Bezeichnung
    CD11a (ITGAL Produkte)
    Synonyme
    CD11A antikoerper, LFA-1 antikoerper, LFA1A antikoerper, (p180) antikoerper, Cd11a antikoerper, LFA-1A antikoerper, Ly-15 antikoerper, Ly-21 antikoerper, CD11a antikoerper, ITGAL antikoerper, integrin subunit alpha L antikoerper, integrin alpha L antikoerper, ITGAL antikoerper, Itgal antikoerper
    Hintergrund
    Synonyms: Integrin αL chain, LFA-1 α chain
    Pathways
    Activated T Cell Proliferation, Integrin Complex
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