ESRRA Antikörper (C-Term)

Produktnummer ABIN2668679

Der Kaninchen Polyklonal anti-ESRRA Antikörper (ABIN2668679) detektiert spezifisch ESRRA in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für ESRRA Antikörper (C-Term) (ABIN2668679)

Target: ESRRA (Estrogen-Related Receptor alpha (ESRRA))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ESRRA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-ESRRA Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: ERR-a antibody (pAb)

Aufreinigung: Affinity Purified

Immunogen: This ERR-alpha antibody was raised against a peptide within the C-terminal region of human ERR alpha.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:500 - 1:1,000 dilution

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

Lagerung: -20 °C

Informationen zur Lagerung: Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

Haltbarkeit: 24 months

Details zu ESRRA

Target: ESRRA (Estrogen-Related Receptor alpha (ESRRA))

Andere Bezeichnung: ERR-alpha

Hintergrund: ERR-a (Estrogen-related receptor alpha, NR3B1) is an orphan nuclear receptor similar to the Estrogen Receptor. It is a sequence-specific DNA binding transcriptional activator that is constitutively active in the absence of ligand binding. No true physiological ligands have been found, but estrogen-like compounds from plants have been shown to activate ERR-a. ERR-a and ER-a have been found to regulate an overlapping set of genes, and ERR-a appears to modulate the activity of ER-a in some tissue types. ERR-a regulates genes involved in mitochondrial biogenesis, gluconeogenesis, oxidative phosphorylation, and fatty acid metabolism. ERR-a knockout mice display impaired fat metabolism and absorption.

Molekulargewicht: 50 kDa

Gen-ID: 2101

NCBI Accession: NP_004442

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha