AIM2 Antikörper (AA 1-186)

Produktnummer ABIN2666308

Der Maus Monoklonal Anti-AIM2-Antikörper wurde für FACS validiert. Er ist geeignet, AIM2 in Proben von Human zu detektieren.

Kurzübersicht für AIM2 Antikörper (AA 1-186) (ABIN2666308)

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser AIM2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Klon: 3B10

Produktdetails anti-AIM2 Antikörper

Bindungsspezifität: AA 1-186

Aufreinigung: The antibody was purified by affinity chromatography.

Immunogen: AA 1-186 of human AIM2 with GST tag.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, 0.09 % Sodium azide.

Lagerung: 4 °C

Informationen zur Lagerung: Upon receipt, store undiluted between 2°C and 8°C.

Details zu AIM2

Target: AIM2 (Absent in Melanoma 2 (AIM2))

Andere Bezeichnung: AIM2

Hintergrund: AIM2 is one of the human IFN-inducible proteins, encoding a 39 kD protein. It contains a 200 amino acid repeat, which is a signature of the HIN-200 family (hematopoietic IFN-inducible nuclear proteins). Expression of AIM2 can inhibit cell growth and tumor formation, possibly through inducing apoptosis and suppressing nuclear factor-kappa B transcriptional activity and desensitizing tumor necrosis factor-alpha-mediated nuclear factor-kappa B activation. Furthermore, the gene for AIM2 shows a high frequency of mutations associated with microsatellite unstable colorectal cancers. AIM2 plays a critical role in the activation of caspase-1, the protease responsible for the processing of pro-inflammatory cytokines IL-1β and IL-18. AIM2 is also essential for mediating inflammatory reactions triggered by cytoplasmic DNA. AIM2 is an important sensor for different pathogens through the binding of cytoplasmic double-stranded DNA through HIN-200 domain and formation of inflammatsomes including ASC/AIM2. This complex then triggers caspase-1 activation. Recent studies also show that AIM2/ASC complex acts as a novel caspase-8 activation platform.

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome