Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

AIM2 Antikörper (AA 1-186)

AIM2 Reaktivität: Human FACS Wirt: Maus Monoclonal 3B10 unconjugated
Produktnummer ABIN2666308
  • Target Alle AIM2 Antikörper anzeigen
    AIM2 (Absent in Melanoma 2 (AIM2))
    Bindungsspezifität
    • 16
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-186
    Reaktivität
    • 70
    • 25
    • 19
    • 3
    • 3
    • 1
    Human
    Wirt
    • 57
    • 12
    • 2
    Maus
    Klonalität
    • 62
    • 9
    Monoklonal
    Konjugat
    • 38
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser AIM2 Antikörper ist unkonjugiert
    Applikation
    • 59
    • 30
    • 29
    • 19
    • 13
    • 13
    • 11
    • 10
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    Flow Cytometry (FACS)
    Aufreinigung
    The antibody was purified by affinity chromatography.
    Immunogen
    AA 1-186 of human AIM2 with GST tag.
    Klon
    3B10
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product AIM2 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    0.5 mg/mL
    Buffer
    phosphate-buffered solution, pH 7.2, 0.09 % Sodium azide.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Upon receipt, store undiluted between 2°C and 8°C.
  • Target
    AIM2 (Absent in Melanoma 2 (AIM2))
    Andere Bezeichnung
    AIM2 (AIM2 Produkte)
    Hintergrund
    AIM2 is one of the human IFN-inducible proteins, encoding a 39 kD protein. It contains a 200 amino acid repeat, which is a signature of the HIN-200 family (hematopoietic IFN-inducible nuclear proteins). Expression of AIM2 can inhibit cell growth and tumor formation, possibly through inducing apoptosis and suppressing nuclear factor-kappa B transcriptional activity and desensitizing tumor necrosis factor-alpha-mediated nuclear factor-kappa B activation. Furthermore, the gene for AIM2 shows a high frequency of mutations associated with microsatellite unstable colorectal cancers. AIM2 plays a critical role in the activation of caspase-1, the protease responsible for the processing of pro-inflammatory cytokines IL-1β and IL-18. AIM2 is also essential for mediating inflammatory reactions triggered by cytoplasmic DNA. AIM2 is an important sensor for different pathogens through the binding of cytoplasmic double-stranded DNA through HIN-200 domain and formation of inflammatsomes including ASC/AIM2. This complex then triggers caspase-1 activation. Recent studies also show that AIM2/ASC complex acts as a novel caspase-8 activation platform.
    Pathways
    Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome
Sie sind hier:
Kundenservice