IRF1 Antikörper

Produktnummer ABIN2666257

Der Maus Monoklonal Anti-IRF1-Antikörper wurde für WB validiert. Er ist geeignet, IRF1 in Proben von Human zu detektieren.

Kurzübersicht für IRF1 Antikörper (ABIN2666257)

Target: IRF1 (Interferon Regulatory Factor 1 (IRF1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IRF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 13H3A44

Produktdetails anti-IRF1 Antikörper

Aufreinigung: Affinity purified.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Upon receipt, store undiluted at 4°C.

Details zu IRF1

Target: IRF1 (Interferon Regulatory Factor 1 (IRF1))

Andere Bezeichnung: IRF1

Hintergrund: IRF1 is the first identified member of the interferon regulatory transcription factor family. Its expression is induced in response to pathogen infection or the stimulation of several cytokines, including type I and II IFN, IL-1, IL-6, and TNF-α. Upon stimulation, IRF1 is transcriptionally activated by STAT1 and NFκB transcription factors via the GAS (interferon-gamma-activated sequence) element in the IRF1 promoter. IRF1 plays important roles in mediating immune response during infection and development of T cells and NK cells. In addition to the immunomodulatory functions, IRF1 has also shown to be involved in the regulation of cell cycle progression, tumor suppression, and apoptosis. IRF1-mediated transcription can be repressed by IRF2 through competing for the same binding region on the promoters.

Pathways: Interferon-gamma Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Immune Effector Process, Hepatitis C, Autophagie