DDX58 Antikörper

Produktnummer ABIN2664928

Produktdetails anti-DDX58 Antikörper

Target: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DDX58 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS)

Aufreinigung: The antibody was purified by affinity chromatography.

Klon: 9F1B20

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C.

Details zu DDX58

Target: DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))

Andere Bezeichnung: DDX58 (DDX58 Produkte)

Synonyme: RIG-I antikoerper, RIGI antikoerper, RLR-1 antikoerper, 6430573D20Rik antikoerper, C330021E21 antikoerper, RHIV-1 antikoerper, RIG-1 antikoerper, DExD/H-box helicase 58 antikoerper, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 antikoerper, DEXD/H-box helicase 58 antikoerper, DDX58 antikoerper, Ddx58 antikoerper

Hintergrund: DDX58, also named RIG-1, is a member of the DExD/H-box-containing RNA helicase family. DDX58 was first reported as a retinoic acid-inducible gene and subsequently characterized as a pattern recognition receptor (PRR). DDX58 is responsible for sensing cytosolic viral RNA and has been shown to initiate innate antiviral immune responses. DDX58 is composed of two caspase recruitment domains (CARDs), a helicase domain, and a C-terminal regulatory domain (CTD). In response to virus infections, the DDX58 CTD domain binds 5'-triphosphorylated dsRNA, which induces multimerization of DDX58 with the adaptor molecule MAVS on the mitochondria through the CARD domains. MAVS transduces the signal to activate downstream transcription factors, such as IRF-3, IRF-7, and NF-κB, leading to production of proinflammatory cytokines and type I interferons.

Pathways: Activation of Innate immune Response, Hepatitis C