CTLA4
(Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))
Reaktivität
Maus
Wirt
Hamster
Klonalität
Monoklonal
Konjugat
Dieser CTLA4 Antikörper ist konjugiert mit Biotin
Applikation
Intracellular Flow Cytometry (ICFC)
Aufreinigung
The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
CD152, also known as CTLA-4 or Ly-56, is a 33 kD member of the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes. CD152 is similar to CD28 in amino acid sequence, structure, and genomic organization and these two receptors share common B7 family counter-receptors (B7-1, B7-2). Whereas CD28 delivers a costimulatory signal in T cell activation, CTLA-4 negatively regulates cell-mediated immune responses. CD152 is thought to play a role in the induction and maintenance of immunological tolerance as well as the development of protective immunity and thymocyte regulation.