CD44 Antikörper (Alexa Fluor 594)

Produktnummer ABIN2656833

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch CD44 in FACS. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für CD44 Antikörper (Alexa Fluor 594) (ABIN2656833)

Target: CD44

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser CD44 Antikörper ist konjugiert mit Alexa Fluor 594

Applikation: Flow Cytometry (FACS)

Klon: IM7

Produktdetails anti-CD44 Antikörper (Alexa Fluor 594)

Kreuzreaktivität: Schimpanse, Pavian, Cynomolgus, Rhesusaffen, Squirrel Monkey (Saimiri spec.), Pferd, Rind (Kuh), Schwein, Hund, Katze

Aufreinigung: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 594 under optimal conditions. The solution is free of unconjugated Alexa Fluor® 594.

Isotyp: IgG2b kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Protect from prolonged exposure to light. Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: The antibody solution should be stored undiluted between 2°C and 8°C

Details zu CD44

Target: CD44

Andere Bezeichnung: CD44

Hintergrund: CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

Pathways: Glycosaminoglycan Metabolic Process, Autophagie, Negative Regulation of intrinsic apoptotic Signaling