CHEK2 Antikörper
Kurzübersicht für CHEK2 Antikörper (ABIN265349)
Target
Alle CHEK2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
-
-
Spezifität
- Chk2 (Q510) antibody detects endogenous levels of Chk2 protein. Species: Human. Others not tested.
-
Produktmerkmale
- Synonyms: CHEK2, CHEK-2, CHK-2, RAD53, Cds1, Serine/threonine-protein kinase Chk2, CHK2checkpoint homolog
-
Aufreinigung
- Aff - Purified
-
-
anti-Checkpoint Kinase 2 (CHEK2) (pThr387) antibody
CHEK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 Reaktivität: Human WB, ELISA, IF, IHC (p) Wirt: Maus Monoclonal 4B7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 Reaktivität: Human WB, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr383) antibodyCHEK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pSer516) antibodyCHEK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr68) antibodyCHEK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reaktivität: Human, Affe, Hund WB, IHC, IF, IHC (p), FACS Wirt: Maus Monoclonal 10G7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reaktivität: Human, Hund WB, IHC, IF, IHC (p), IP, FACS Wirt: Maus Monoclonal 5C4 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reaktivität: Human, Hund WB, IHC, IHC (p), IP, FACS Wirt: Maus Monoclonal 2H5 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyKD Validated CHEK2 Reaktivität: Human WB, IF (p), FACS Wirt: Kaninchen Monoclonal 23GB3460 unconjugated Recombinant Antibody
-
-
Applikationshinweise
- ELISA: 1: 20000~1: 40000. WB: 1: 500~1: 1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
-
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Lagerung
- 4 °C
-
Informationen zur Lagerung
- Store the antibody undiluted at 2-8°C. DO NOT FREEZE! Shelf life: one year from despatch.
-
Haltbarkeit
- 12 months
-
-
- CHEK2 (Checkpoint Kinase 2 (CHEK2))
-
Andere Bezeichnung
- CHK2
-
Hintergrund
- Cell cycle events are regulated by the sequential activation and deactivation of cyclindependent kinases (Cdks) and by proteolysis of cyclins. Chk1 and Chk2 are involved inthese processes as regulators of Cdks. Chk1 and Chk2 both function as essentialcomponents in the G2 DNA damage checkpoint by phosphorylating Cdc25C in response toDNA damage. Phosphorylation inhibits Cdc25C activity, thereby blocking mitosis. Cdc25A,Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators bydephosphorylating Cdc2 p34 on regulatory tyrosine residues. It has also been shown thatChk1 can phosphorylate Wee1 in vitro, providing evidence that the hyperphosphorylatedform of Wee1, seen in cells delayed by Chk1 overexpression, is due to phosphorylation byChk1.
-
UniProt
- O96017
-
Pathways
- p53 Signalweg, Apoptose, Zellzyklus
Target
-
