LY96 Antikörper (Middle Region)

Produktnummer ABIN265133

Der Kaninchen Polyklonal anti-LY96 Antikörper wird verwendet zum Nachweis von LY96 in Proben von Human, Maus und Ratte. Er wurde validiert für WB und IHC (fro).

Kurzübersicht für LY96 Antikörper (Middle Region) (ABIN265133)

Target: LY96 (Lymphocyte Antigen 96 (LY96))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LY96 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-LY96 Antikörper

Bindungsspezifität: Middle Region

Aufreinigung: Purified

Immunogen: Rabbit polyclonal MD-2 antibody was raised against a peptide corresponding to amino acids near the middle region of human MD-2.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 0,5 - 1 μg/mL. Immunohistochemistry. Found in the liver and spleen, the secreted protein Lymphocyte antigen 96/MD-2ooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS),and with TLR2 in the response to cell wall components from Gram-positive andGram-negative bacteria.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu LY96

Target: LY96 (Lymphocyte Antigen 96 (LY96))

Andere Bezeichnung: MD-2

Hintergrund: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1 - 3). TLRs are signaling molecules that recognize different pathogenassociated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS (5,6). The specificity of this response is determined by the species of MD-2, e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4 (7).Synonyms: ESOP-1, ESOP1, LY96, Lymphocyte antigen 96, MD2

Gen-ID: 9606

UniProt: Q9Y6Y9

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades