LY86 Antikörper (C-Term)

Produktnummer ABIN265131

Dieses Anti-LY86-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von LY86 in WB. Geeignet für Human.

Kurzübersicht für LY86 Antikörper (C-Term) (ABIN265131)

Target: LY86 (Lymphocyte Antigen 86 (LY86))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LY86 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-LY86 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to Lymphocyte Antigen 86/MD-1.

Aufreinigung: Purified

Immunogen: Rabbit polyclonal MD-1 antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human MD-1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 0,5 - 1 μg/mL. May cooperate with CD180 and TLR4 to mediate the innate immune response to bacteriallipopolysaccharide (LPS) and cytokine production. Important for efficie nt CD180 cellsurface expression.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody can be shipped at ambient temperature. Store (in aliquots) at -20 °C only.

Details zu LY86

Target: LY86 (Lymphocyte Antigen 86 (LY86))

Andere Bezeichnung: LY86 / MD-1

Hintergrund: Toll-like receptors (TLRs) are evolutionarily conserved patternrecognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway.. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD -1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.Synonyms: Lymphocyte antigen 86, MD1

Gen-ID: 9450

NCBI Accession: NP_004262

UniProt: O95711

Pathways: Toll-Like Receptors Cascades