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ADAM17 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch ADAM17 in WB. Er zeigt eine Reaktivität gegenüber Human, Ratte und Maus.
Produktnummer ABIN264994

Kurzübersicht für ADAM17 Antikörper (C-Term) (ABIN264994)

Target

Alle ADAM17 Antikörper anzeigen
ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

Reaktivität

  • 112
  • 50
  • 47
  • 3
  • 3
  • 3
  • 1
Human, Ratte, Maus

Wirt

  • 92
  • 22
  • 1
  • 1
  • 1
  • 1
Kaninchen

Klonalität

  • 83
  • 35
Polyklonal

Konjugat

  • 64
  • 8
  • 7
  • 5
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser ADAM17 Antikörper ist unkonjugiert

Applikation

  • 90
  • 48
  • 39
  • 22
  • 19
  • 15
  • 14
  • 13
  • 12
  • 10
  • 4
  • 4
  • 3
  • 2
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 16
    • 10
    • 8
    • 8
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 807-823, C-Term

    Spezifität

    This antibody Detects TACE (ADAM17/CD156b).

    Aufreinigung

    Immunoaffinity Chromatography.

    Immunogen

    Synthetic peptide corresponding to amino acids 807 to 823 of the human TACE protein. Immunogen sequence differs from the mouse and rat sequences by one amino acid.

    Isotyp

    IgG
  • Applikationshinweise

    Western Blot (0.25-1 μg/mL): Detects an approximately 130 kDa band in HeLa and Jurkatwhole cell lysate which may represent mature protein, precursor, and glycosylated TACE.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Buffer

    Phosphate buffered saline solution containing 0.02 % Sodium Azide as a preservative.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    DO NOT FREEZE!

    Lagerung

    4 °C

    Informationen zur Lagerung

    The antibody can be shipped at ambient temperature. Store (in aliquots) at 2-8 °C.
  • Target

    ADAM17 (ADAM Metallopeptidase Domain 17 (ADAM17))

    Andere Bezeichnung

    CD156b / ADAM17

    Hintergrund

    Tumor-necrosis factor-a is a proinflammatory cytokine and contributes to a variety of inflammatory disease responses and programmed cell death. TNF-a is synthesized as a 26K type II membrane-bound precursor that is cleaved by a convertase to generate secreted 17K mature TNF-a. TNF-a converting enzyme (TACE) protein was recently purified and the human and mouse TACE cDNAs were cloned by several groups separately (1-3). TACE is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease). TACE also processes other cell surface proteins, including TNF receptor, TGFa, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP) (4,5). TACE mRNA is expressed in a variety of human and murine tissues. TACE was selected as one of the few targets in cytokine activation by the Eighth International Conference of the Inflammation Research Association. (6)Synonyms: CSVP, Disintegrin and metalloproteinase domain-containing protein 17, Snake venom-like protease, TACE, TNF-alpha convertase, TNF-alpha-converting enzyme

    Gen-ID

    6868

    NCBI Accession

    NP_003174

    UniProt

    P78536

    Pathways

    Notch Signalweg, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Response to Growth Hormone Stimulus
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