Retinoblastoma 1 Antikörper (AA 300-380)
Kurzübersicht für Retinoblastoma 1 Antikörper (AA 300-380) (ABIN264374)
Target
Alle Retinoblastoma 1 (RB1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 300-380
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Spezifität
- Retinoblastoma binds and regulates E2F transcription factors.
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Produktmerkmale
- Synonyms: Retinoblastoma 1, Rb, p105-Rb, pRb, pp110, OSRC
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Aufreinigung
- From ascites.
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Immunogen
- Recombinant protein corresponding to amino acids 300 to 380 of the humanretinoblastoma sequence.
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Isotyp
- IgG1
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Applikationshinweise
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Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Buffer
- PBS containing 0.08 % Sodium Azide as preservative.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
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Store the antibody at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch. -
Haltbarkeit
- 12 months
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- Retinoblastoma 1 (RB1)
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Andere Bezeichnung
- Retinoblastoma-Associated Protein / RB1
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Hintergrund
- Retinoblastoma encodes a phosphorylated protein p110 and binds and regulates E2F transcription factors. Rb functions as a major cell cycle regulator by its ability to repress gene transcription by all three RNA polymerases. In its hypophosphorylated form, Rb binds to a subset of E2F containing complexes converting them to repressors preventing expression of E2F target genes. These complexes repress transcription via E2F binding elements in the promotersof cell cycle control genes, such as E2F-1, c-myc, and cdc2 genes.Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110
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Gen-ID
- 5925
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UniProt
- P06400
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Pathways
- Zellzyklus, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagie
Target
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