Aktivieren Sie Javascript in Ihrem Browser, um unsere Webseite optimal zu nutzen.

PD-1 Antikörper (PE)

PDCD1 Reaktivität: Maus FACS Wirt: Hamster Monoclonal J43-1 PE

Produktnummer ABIN2567419

Datenblatt (PDF)

Target Alle PD-1 (PDCD1) Antikörper anzeigen

PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
Reaktivität
155

94

26

5

3

1
Maus
Wirt
84

76

37

13

12

2

2

1

1
Hamster
Klonalität
163

59

5
Monoklonal
Konjugat
109

17

14

14

7

7

4

4

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser PD-1 Antikörper ist konjugiert mit PE
Applikation
145

64

48

46

38

20

13

13

13

11

11

10

9

7

6

5

4

4

4

4

3

3

2

2

2

1

1

1

1

1

1
Flow Cytometry (FACS)

Spezifität

The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily.

Aufreinigung

The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Klon

J43-1

Isotyp

IgG

Top Product

Discover our top product PDCD1 Primärantikörper
anti-Programmed Cell Death 1 (PDCD1) (AA 201-288) antibody
PDCD1 Reaktivität: Human, Maus, Ratte FACS, WB, ELISA, IHC (p), IHC (fro), IF (p), IF (cc) Wirt: Kaninchen Polyclonal unconjugated

anti-Programmed Cell Death 1 (PDCD1) (AA 41-132) antibody
PDCD1 Reaktivität: Human WB, ELISA, IHC (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated

anti-Programmed Cell Death 1 (PDCD1) (AA 192-288) antibody
PDCD1 Reaktivität: Human FACS, WB, ELISA Wirt: Maus Monoclonal 3B3D9 unconjugated

anti-Programmed Cell Death 1 (PDCD1) (AA 192-288) antibody
PDCD1 Reaktivität: Human FACS, ELISA Wirt: Maus Monoclonal 8G5B12 unconjugated

anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibody
PDCD1 Reaktivität: Human FACS, WB, ELISA Wirt: Maus Monoclonal 1D6F6 unconjugated

anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibody
PDCD1 Reaktivität: Human FACS, ELISA, ICC Wirt: Maus Monoclonal 3E12A10 unconjugated

anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibody
PDCD1 Reaktivität: Human WB, IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated

anti-Programmed Cell Death 1 (PDCD1) (AA 1-288) antibody
PDCD1 Reaktivität: Human WB Wirt: Maus Polyclonal unconjugated

anti-Programmed Cell Death 1 (PDCD1) antibody
PDCD1 Reaktivität: Human IHC, ELISA, StM, Coat Wirt: Maus Monoclonal PDCD1-2720 unconjugated

anti-Programmed Cell Death 1 (PDCD1) antibody
PDCD1 Reaktivität: Human, Non-Human Primate FACS, IHC (fro) Wirt: Maus Monoclonal EH12-2H7 unconjugated

Applikationshinweise

Optimal working dilution should be determined by the investigator.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Format

Liquid

Konzentration

0.2 mg/mL

Buffer

Phosphate-buffered aqueous solution, ≤0.09 % Sodium azide, may contain carrier protein/stabilizer, ph7.2.

Lagerung

4 °C

Informationen zur Lagerung

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Target

PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Andere Bezeichnung

CD279 (PDCD1 Produkte)

Hintergrund

The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.

Gen-ID

18566

UniProt

Q02242

Pathways

Cancer Immune Checkpoints