PD-1 Antikörper
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- Target Alle PD-1 (PDCD1) Antikörper anzeigen
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
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Reaktivität
- Maus
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Wirt
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Hamster
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Klonalität
- Monoklonal
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Konjugat
- Dieser PD-1 Antikörper ist unkonjugiert
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Applikation
- Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Functional Studies (Func)
- Spezifität
- The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily.
- Aufreinigung
- The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/μg of the protein.
- Klon
- J43-1
- Isotyp
- IgG
- Top Product
- Discover our top product PDCD1 Primärantikörper
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anti-Programmed Cell Death 1 (PDCD1) (AA 201-288) antibody
PDCD1 Reaktivität: Human, Maus, Ratte FACS, WB, ELISA, IHC (p), IHC (fro), IF (p), IF (cc) Wirt: Kaninchen Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 41-132) antibodyPDCD1 Reaktivität: Human WB, ELISA, IHC (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 192-288) antibodyPDCD1 Reaktivität: Human FACS, WB, ELISA Wirt: Maus Monoclonal 3B3D9 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 192-288) antibodyPDCD1 Reaktivität: Human FACS, ELISA Wirt: Maus Monoclonal 8G5B12 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 Reaktivität: Human FACS, WB, ELISA Wirt: Maus Monoclonal 1D6F6 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 Reaktivität: Human FACS, ELISA, ICC Wirt: Maus Monoclonal 3E12A10 unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 21-170) antibodyPDCD1 Reaktivität: Human WB, IHC, ELISA, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) (AA 1-288) antibodyPDCD1 Reaktivität: Human WB Wirt: Maus Polyclonal unconjugated
anti-Programmed Cell Death 1 (PDCD1) antibodyPDCD1 Reaktivität: Human IHC, ELISA, StM, Coat Wirt: Maus Monoclonal PDCD1-2720 unconjugated
anti-Programmed Cell Death 1 (PDCD1) antibodyPDCD1 Reaktivität: Human, Non-Human Primate FACS, IHC (fro) Wirt: Maus Monoclonal EH12-2H7 unconjugated
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 2.0 mg/mL
- Buffer
- Phosphate-buffered aqueous solution, ph7.2.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- The product should be stored undiluted at 4°C. Do not freeze.
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- Target
- PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))
- Andere Bezeichnung
- CD279 (PDCD1 Produkte)
- Hintergrund
- The J43.1 monoclonal antibody specifically reacts with mouse CD279, also known as PD-1 (programmed death-1), a 50-55 kDa glycoprotein of the Ig superfamily. The PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-H2) are members of the B7 family. Pd-1 contains an Immunoreceptor Tyrosine-based Inhibitory Motif (ITIM) and influences the peripheral tolerances and autoimmune diseases in mice. PD-1 is transiently expressed on CD4/CD8 thymocytes, it is upregulated in apoptotic cells, and it is expressed by activated myeloid and T and B cells. The binding of PD-1 to its ligands is blocked by the J43 antibody, which also enhances contact hypersensitivity and exacerbates acute Graft-versus-host disease, Experimental autoimmune encephalomyelitis and NOD diabetes. PD-1 seems to downregulate the immune response, as the development of splenomegaly and breakdown of peripheral tolerance in PD-1 deficient mice suggests.
- Gen-ID
- 18566
- UniProt
- Q02242
- Pathways
- Cancer Immune Checkpoints
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