Integrin beta 2 Antikörper

Produktnummer ABIN2567290

Der Ratte Monoklonal anti-Integrin beta 2 Antikörper (Klon M18-2) (ABIN2567290) detektiert spezifisch Integrin beta 2 in FACS und Func. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für Integrin beta 2 Antikörper (ABIN2567290)

Target: Integrin beta 2 (ITGB2)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Functional Studies (Func)

Klon: M18-2

Produktdetails anti-Integrin beta 2 Antikörper

Spezifität: The M18/2 monoclonal antibody specifically binds to mouse CD18, a 95kDA integrin beta 2 glycoprotein.

Aufreinigung: The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/μg of the protein.

Isotyp: IgG2a kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Phosphate-buffered aqueous solution, ph7.2.

Lagerung: 4 °C

Informationen zur Lagerung: The product should be stored undiluted at 4°C. Do not freeze.

Details zu Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Andere Bezeichnung: CD18

Hintergrund: The M18/2 monoclonal antibody specifically binds to mouse CD18, a 95kDA integrin beta 2 glycoprotein. CD18 is expressed on all leukocytes with the highest density by NK and T cells. CD18 forms LFA-1 with CD11a, Mac-1 with CD11b and gp150/95 with CD11c. Through these interactions, CD18 has an important role in cellular adhesion. The M18/2 antibody is reported to stimulate Mac-1 and LFA-1 adhesion to their ligands and block tumor cell metastasis.

Gen-ID: 16414

UniProt: P11835

Pathways: NF-kappaB Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation