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P4HB Antikörper (AA 409-509) (PerCP)

P4HB Reaktivität: Ratte WB, IHC, IP, IF, ICC Wirt: Kaninchen Polyclonal PerCP
Produktnummer ABIN2486779
  • Target Alle P4HB Antikörper anzeigen
    P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
    Bindungsspezifität
    • 20
    • 19
    • 15
    • 13
    • 11
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 409-509
    Reaktivität
    • 108
    • 75
    • 65
    • 23
    • 22
    • 22
    • 20
    • 18
    • 18
    • 16
    • 10
    • 10
    • 8
    • 7
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 117
    • 27
    • 2
    Kaninchen
    Klonalität
    • 108
    • 38
    Polyklonal
    Konjugat
    • 63
    • 16
    • 15
    • 9
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser P4HB Antikörper ist konjugiert mit PerCP
    Applikation
    • 112
    • 67
    • 44
    • 44
    • 43
    • 35
    • 18
    • 15
    • 14
    • 13
    • 13
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Detects ~58 kDa.
    Kreuzreaktivität
    Rind (Kuh), Hund, Meerschweinchen, Hamster, Human, Mollusca, Maus, Schwein, Ratte, Schaf, Xenopus laevis
    Aufreinigung
    Peptide Affinity Purified
    Immunogen
    Rat PDI synthetic peptide (409-509 aa C-terminal) conjugated to KLH
    Top Product
    Discover our top product P4HB Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    A 1:1000 dilution of ABIN2486779 was sufficient for detection of PDI in 20 μg of HeLa cell lysate by ECL immunoblot analysis.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))
    Andere Bezeichnung
    PDI (P4HB Produkte)
    Synonyme
    DSI antikoerper, ERBA2L antikoerper, GIT antikoerper, P4Hbeta antikoerper, PDI antikoerper, PDIA1 antikoerper, PHDB antikoerper, PO4DB antikoerper, PO4HB antikoerper, PROHB antikoerper, PDA2 antikoerper, PDIP antikoerper, PDIR antikoerper, ERp59 antikoerper, Pdia1 antikoerper, Thbp antikoerper, p55 antikoerper, XPDIp antikoerper, pdi antikoerper, 1810041F13Rik antikoerper, AI661267 antikoerper, Pdip antikoerper, Pdipl antikoerper, p58 antikoerper, prolyl 4-hydroxylase subunit beta antikoerper, protein disulfide isomerase family A member 2 antikoerper, prolyl 4-hydroxylase, beta polypeptide antikoerper, protein disulfide isomerase family A member 2 L homeolog antikoerper, protein disulfide isomerase associated 2 antikoerper, prolyl 4-hydroxylase subunit beta L homeolog antikoerper, protein disulfide-isomerase antikoerper, P4HB antikoerper, PDIA2 antikoerper, P4hb antikoerper, pdia2.L antikoerper, Pdia2 antikoerper, p4hb.L antikoerper, LOC8281065 antikoerper
    Hintergrund
    The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation via its oxidase activity and isomerization via its isomerase activity, as well as the reduction of disulphide bonds in proteins (1). Studies suggest BiP and PDI work together sequentially to increase oxidation of these proteins (2, 3). PDI has also been found to function as a chaperone to prevent the aggregation of unfolded substrates, and serves as a subunit of prolyl 4-hydroxylase and microsomal triglyceride transferase (4, 5). PDI is an abundant 55 kDa protein located primarily in the ER, however studies have also proved its presence in the cytosol (1). PDI has the ability to reside in the ER permanently due to the highly conserved KDEL sequence at its carboxy-terminus (6). It uses carboxy-terminal KDEL as a retention signal, and this appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor (7).
    Gen-ID
    287164
    NCBI Accession
    NP_001099245
    UniProt
    P04785
    Pathways
    Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism
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