NALCN Antikörper (AA 1659-1738) (PE)

Produktnummer ABIN2483034

Dieses Maus Monoklonal-Antikörper erkennt spezifisch NALCN in WB, ICC und IF. Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für NALCN Antikörper (AA 1659-1738) (PE) (ABIN2483034)

Target: NALCN (Sodium Leak Channel, Non-Selective (NALCN))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NALCN Antikörper ist konjugiert mit PE

Applikation: Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

Klon: S187-7

Produktdetails anti-NALCN Antikörper (PE)

Bindungsspezifität: AA 1659-1738

Spezifität: Detects ~200 kDa.

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Protein G Purified

Immunogen: Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

• WB (1:1000)
• ICC/IF (1:100)
• optimal dilutions for assays should be determined by the user.

Kommentare:

1 μg/ml of ABIN2483034 was sufficient for detection of NALCN in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Conjugated antibodies should be stored at 4°C

Details zu NALCN

Target: NALCN (Sodium Leak Channel, Non-Selective (NALCN))

Andere Bezeichnung: NALCN

Hintergrund: NALCN (sodium leak channel non-selective protein), alsoknown as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events.

Gen-ID: 266760

NCBI Accession: NP_705894

UniProt: Q6Q760