NALCN Antikörper (Domain 3, Extracellular)

Produktnummer ABIN7887119

Der Kaninchen Polyklonal anti-NALCN Antikörper (ABIN7887119) detektiert spezifisch NALCN in WB, IF, IHC, IC und LCI. Dieser Antikörper reagiert spezifisch mit Proben aus Ratte.

Kurzübersicht für NALCN Antikörper (Domain 3, Extracellular) (ABIN7887119)

Target: NALCN (Sodium Leak Channel, Non-Selective (NALCN))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NALCN Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunochromatography (IC), Live Cell Imaging (LCI)

Produktdetails anti-NALCN Antikörper

Bindungsspezifität: AA 902-914, Domain 3, Extracellular

Verwendungszweck: A Rabbit Polyclonal Antibody to Sodium Leak Channel Non-Selective Protein (NALCN)

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Mouse,human - identical

Produktmerkmale: Anti-NALCN/VGCNL1 (extracellular) Antibody (ABIN7043658 and ABIN7045249) is a highly specific antibody directed against an epitope of rat Sodium leak channel non-selective protein. The antibody can be used in western blot, immunohistochemistry and live cell imaging applications. It has been designed to recognize NALCN from mouse, rat, and human samples.

Aufreinigung: Affinity purified on immobilized antigen.

Immunogen: (C)SMMFESPFRRVMH, corresponding to amino acid residues 902-914 of rat NALCN

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:50

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Kommentare:

Negative Control: (ABIN7236886)

Blocking Peptide: (ABIN7236886)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Konzentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Details zu NALCN

Target: NALCN (Sodium Leak Channel, Non-Selective (NALCN))

Andere Bezeichnung: NALCN

Hintergrund:

Synonyms: Sodium leak channel non-selective protein, Voltage gated channel-like protein 1, Four domain-type voltage-gated ion channel alpha-1 subunit, CanIon, Rb21-channel

Description: The existence of resting K+ conductance has been known for some time. Only recently has the Nalcn (sodium leak channel non-selective protein) been found responsible for the resting Na+ conductance1.Nalcn is a member of the NaV and CaV channel family which have four homologous repeats of six transmembrane domains. One structural difference is that Nalcn is less positively charged in the voltage sensing segment1. The protein forms voltage-independent non-inactivating channel which is permeable to Na+, K+ and Ca2+ ions1,2.Evidence suggests that Nalcn is a non-redundant and thus essential channel since knock-out mice display disrupted respiratory rhythm and die within 24 hours of birth. In addition, isolated neurons from these mice have decreased excitability1.The channel is extensively expressed in the central nervous system1, heart, pituitary and adrenal glands and pancreatic islet cells2,3.In pancreatic islets, Nalcn is activated by acetylcholine via its physical association with M3 muscarinic receptor, and potentiates insulin secretion induced by glucose uptake2-4.

Gen-ID: 266760

NCBI Accession: NM_052867

UniProt: Q6Q760