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NALCN Antikörper (AA 1659-1738)

NALCN Reaktivität: Ratte ICC, IF, WB Wirt: Maus Monoclonal S187-7 unconjugated
Produktnummer ABIN1686626
$474.50
Zzgl. Versandkosten $45.00
100 μg
Lieferung in 3 bis 4 Werktagen
  • Target Alle NALCN Antikörper anzeigen
    NALCN (Sodium Leak Channel, Non-Selective (NALCN))
    Bindungsspezifität
    • 12
    • 5
    • 2
    • 1
    • 1
    • 1
    AA 1659-1738
    Reaktivität
    • 15
    • 7
    • 5
    • 1
    Ratte
    Wirt
    • 15
    • 8
    Maus
    Klonalität
    • 15
    • 8
    Monoklonal
    Konjugat
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser NALCN Antikörper ist unkonjugiert
    Applikation
    • 18
    • 12
    • 12
    • 4
    • 4
    • 1
    • 1
    • 1
    Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
    Spezifität
    Detects ~200 kDa.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1659-1738 (cytoplasmic C-terminus) of rat NALCN
    Klon
    S187-7
    Isotyp
    IgG1
  • Applikationshinweise
    • WB (1:1000)
    • ICC/IF (1:100)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN1686626 was sufficient for detection of NALCN in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    -20°C
  • Target
    NALCN (Sodium Leak Channel, Non-Selective (NALCN))
    Andere Bezeichnung
    NALCN (NALCN Produkte)
    Synonyme
    VGCNL1, zgc:113349, CanIon, bA430M15.1, A530023G15Rik, AI849508, Vgcnl1, sodium leak channel, non-selective, NALCN, nalcn, Nalcn
    Hintergrund
    NALCN (sodium leak channel non-selective protein), alsoknown as CanIon or VGCNL1 (voltage gated channel-like protein 1), is a 1738 amino acid multi-pass membrane protein that belongs to the cation-nonselective channel family. NALCN is highly conserved in mammals and is widely expressed in the central nervous system. Activated by NK-1R, NALCN is a voltage-independent, nonselective cation channel which is permeable to sodium, potassium and calcium ions. NALCN is responsible for background sodium ion leak conductance in neurons and regulates basal excitability of the nervous systems. Defects of NALCN in mice causes disruption in respiratory rhythm and death occurs within 24 hours of birth. Three isoforms of NALCN exists due to alternative splicing events.
    Gen-ID
    266760
    NCBI Accession
    NP_705894
    UniProt
    Q6Q760
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