FANCA Antikörper (AA 995-1009)

Produktnummer ABIN2470330

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch FANCA in WB, ELISA und IHC. Es zeigt Reaktivität gegenüber Proben von Human und Schimpanse.

Kurzübersicht für FANCA Antikörper (AA 995-1009) (ABIN2470330)

Target: FANCA (Fanconi Anemia Group A Protein (FANCA))

Reaktivität: Human, Schimpanse

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FANCA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Produktdetails anti-FANCA Antikörper

Bindungsspezifität: AA 995-1009

Aufreinigung: Immunoaffinity Chromatography

Immunogen: FANCA antibody was raised against amino acids 995-1009 of FANCA (Human).

Anwendungsinformationen

Applikationshinweise: FANCA antibody can be used in ELISA starting at 1:000 - 1:1000, and immunohistochemistry starting at 20 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies avoid freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store FANCA antibody at 4 °C or -20 °C.

Details zu FANCA

Target: FANCA (Fanconi Anemia Group A Protein (FANCA))

Andere Bezeichnung: FANCA

Hintergrund: FANCA (also called Protein FACA or Fanconi anemia group A protein) is involved in DNA repair, perhaps specifically with post-replication repair or a cell cycle checkpoint function. FANCA may also be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, and FANCL. The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity, they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Variant 1 (isoform a) encodes the longest transcript. Variant 2 (isoform b) contains an alternate exon, which results in an early stop codon, compared to variant 1. Isoform b has a shorter C-terminus when compared to isoform a. Mutations in this gene are the most common cause of Fanconi anemia.

Gen-ID: 2175

UniProt: O15360

Pathways: DNA Reparatur