TRIM5 Antikörper (truncated)

Produktnummer ABIN2464117

Dieser Maus Monoklonal Antikörper detektiert spezifisch TRIM5 in WB und IHC. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TRIM5 Antikörper (truncated) (ABIN2464117)

Target: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TRIM5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Klon: 3B11H2

Produktdetails anti-TRIM5 Antikörper

Bindungsspezifität: truncated

Immunogen: Ni-NTA purified truncated recombinant human trim5 alpha expressed in E. Coli strain BL21 (DE3).

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot:Dilution 1:1,000 - 1:5,000
IHC(P):Dilution 1:100 - 1:400
IHC(F):Dilution 1:200 - 1:400
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Lagerung: -20 °C

Informationen zur Lagerung: Trim5? monoclonal antibody can be stored at -20 °C, stable for one year.

Details zu TRIM5

Target: TRIM5 (Tripartite Motif Containing 5 (TRIM5))

Andere Bezeichnung: Trim5a

Hintergrund: TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.

Gen-ID: 85364

UniProt: Q9NUD5

Pathways: Activation of Innate immune Response